Characterization of synthetic peptide byproducts from cyclization reactions using on-line HPLC-ion spray and tandem mass spectrometry

Engineering & Materials Science

• Cyclization 100%
• Peptides 75%
• Mass spectrometry 73%
• Byproducts 59%
• Ions 52%
• Characterization (materials science) 49%
• Cyclic Peptides 19%
• Lactams 18%
• Derivatives 11%
• Reagents 11%
• Alkylation 7%
• Acids 4%

Medicine & Life Sciences

• Cyclization 85%
• Tandem Mass Spectrometry 62%
• Ions 47%
• High Pressure Liquid Chromatography 47%
• Peptides 36%
• aspartimide 22%
• Cyclic Peptides 13%
• Lactams 13%
• dynorphin (1-13) 7%
• Dynorphins 6%
• Alkylation 6%
• Guanidine 6%
• Mass Spectrometry 4%
• Acids 3%
• HAPyU 1%

Chemical Compounds

• Byproduct 56%
• Spray 53%
• Tandem Mass Spectrometry 47%
• Cyclization Reaction 42%
• Peptide 33%
• Dynorphin A 14%
• Lactam 9%
• Guanidinium 5%
• Ion 5%
• Cyclic Peptide 5%
• Phosphonium 4%
• Retention Time 4%
• Alkylation 3%
• Tris 3%
• Fragmentation 3%
• Cleavage 3%
• Mass Spectrometry 2%
• Purity 2%
• Acid 1%