Characterization of silkworm chlorophyll metabolites as an active photosensitizer for photodynamic therapy

Renke Dai, Richard Shoemaker, David Farrens, Man Jung Han, Choong Sup Kim, Pill Soon Song

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Silkworm excreta containing chlorophyll metabolites have long been used for their medicinal activities in the Far East. The major chlorophyll derivative (CpD) fraction in the Me2CO extract from the silkworm excreta exhibits strong photodynamic action on mice and human tumor cells in vitro. The main CpD component was isolated, purified, and subjected to extensive structural and characterization studies to assess its photodynamic therapeutic activity. According to the spectral analyses, the structure of the major unknown CpD was determined to be 10-hydroxypheophytina [1]. The CpD component possessed a high quantum efficiency (50%) for the photosensitized production of singlet molecular oxygen, thus providing a molecular basis for its photodynamic therapeutic efficiency. A further advantage is that the "photooxidation/ degradation" product(s) from this CpD retains all the characteristics of a photodynamic sensitizer.

Original languageEnglish (US)
Pages (from-to)1241-1251
Number of pages11
JournalJournal of Natural Products
Volume55
Issue number9
StatePublished - 1992
Externally publishedYes

Fingerprint

Photodynamic therapy
Photosensitizing Agents
Bombyx
Photochemotherapy
Chlorophyll
Metabolites
silkworms
metabolites
chlorophyll
chemical derivatives
therapeutics
Derivatives
excreta
Singlet Oxygen
photooxidation
Photooxidation
Far East
Molecular oxygen
Quantum efficiency
East Asia

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Characterization of silkworm chlorophyll metabolites as an active photosensitizer for photodynamic therapy. / Dai, Renke; Shoemaker, Richard; Farrens, David; Han, Man Jung; Kim, Choong Sup; Song, Pill Soon.

In: Journal of Natural Products, Vol. 55, No. 9, 1992, p. 1241-1251.

Research output: Contribution to journalArticle

Dai, Renke ; Shoemaker, Richard ; Farrens, David ; Han, Man Jung ; Kim, Choong Sup ; Song, Pill Soon. / Characterization of silkworm chlorophyll metabolites as an active photosensitizer for photodynamic therapy. In: Journal of Natural Products. 1992 ; Vol. 55, No. 9. pp. 1241-1251.
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