TY - JOUR
T1 - Characterization of MR imaging-visible perivascular spaces in the white matter of healthy adolescents at 3T
AU - Piantino, J.
AU - Boespflug, Erin
AU - Schwartz, D. L.
AU - Luther, M.
AU - Morales, A. M.
AU - Lin, A.
AU - Fossen, R. V.
AU - Silbert, L.
AU - Nagel, B. J.
N1 - Funding Information:
Disclosures: Juan Piantino—RELATED: Grant: National Institutes of Health, Comments: National Heart, Lung, and Blood Institute, K23HL150217-01. Erin Boespflug—RELATED: Grant: National Institutes of Health, Comments: research salary support from National Institutes of Health grants K01AG059842 and P30AG008017.* Amber Lin—RELATED: Grant: National Institutes of Health K12 training grant, Comments: This grant supports my time (biostatistical support) for a number of investigators, including the primary author of this article. Lisa Silbert—UNRELATED: Grants/Grants Pending: National Institutes of Health, Comments: Principal Investigator on a National Institutes of Health R01 and CoInvestigator on several National Institutes of Health grants, not directly related to this article.* Bonnie J. Nagel—RELATED: Grant: National Institute on Alcohol Abuse and Alcoholism, Comments: This work was supported by NIH U01 AA02169.* *Money paid to the institution.
Funding Information:
This work was supported by the National Heart, Lung, and Blood Institute, K23HL150217-01 and K12HL133115; the National Institute on Aging, K01AG059842 and P30 AG008017; and the National Institute on Drug Abuse, K01DA046649.
Publisher Copyright:
© 2020 American Society of Neuroradiology. All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Background and Purpose: Perivascular spaces play a role in cerebral waste removal and neuroinflammation. Our aim was to provide data regarding the burden of MR imaging-visible perivascular spaces in white matter in healthy adolescents using an automated segmentation method and to establish relationships between common demographic characteristics and perivascular space burden. Materials and Methods: One hundred eighteen 12- to 21-year-old subjects underwent T1- and T2-weighted 3T MR imaging as part of the National Consortium on Alcohol and Neurodevelopment in Adolescence. Perivascular spaces were identified in WM on T2-weighted imaging using a local heterogeneity approach coupled with morphologic constraints, and their spatial distribution and geometric characteristics were assessed. Results: MR imaging-visible perivascular spaces were identified in all subjects (range, 16-287). Males had a significantly higher number of perivascular spaces than females: males, mean, 98.4 ± 50.5, versus females, 70.7 ± 36.1, (P,.01). Perivascular space burden was bilaterally symmetric (r>0.4, P<.01), and perivascular spaces were more common in the frontal and parietal lobes than in the temporal and occipital lobes (P<.01). Age and pubertal status were not significantly associated with perivascular space burden. Conclusions: Despite a wide range of burden, perivascular spaces are present in all healthy adolescents. Perivascular space burden is higher in adolescent males than in females, regardless of age and pubertal status. In this population, perivascular spaces are highly symmetric. Although widely reported as a feature of the aging brain, awareness of the presence of perivascular spaces in a cohort of healthy adolescents provides the foundation for further research regarding the role of these structural variants in health and disease.
AB - Background and Purpose: Perivascular spaces play a role in cerebral waste removal and neuroinflammation. Our aim was to provide data regarding the burden of MR imaging-visible perivascular spaces in white matter in healthy adolescents using an automated segmentation method and to establish relationships between common demographic characteristics and perivascular space burden. Materials and Methods: One hundred eighteen 12- to 21-year-old subjects underwent T1- and T2-weighted 3T MR imaging as part of the National Consortium on Alcohol and Neurodevelopment in Adolescence. Perivascular spaces were identified in WM on T2-weighted imaging using a local heterogeneity approach coupled with morphologic constraints, and their spatial distribution and geometric characteristics were assessed. Results: MR imaging-visible perivascular spaces were identified in all subjects (range, 16-287). Males had a significantly higher number of perivascular spaces than females: males, mean, 98.4 ± 50.5, versus females, 70.7 ± 36.1, (P,.01). Perivascular space burden was bilaterally symmetric (r>0.4, P<.01), and perivascular spaces were more common in the frontal and parietal lobes than in the temporal and occipital lobes (P<.01). Age and pubertal status were not significantly associated with perivascular space burden. Conclusions: Despite a wide range of burden, perivascular spaces are present in all healthy adolescents. Perivascular space burden is higher in adolescent males than in females, regardless of age and pubertal status. In this population, perivascular spaces are highly symmetric. Although widely reported as a feature of the aging brain, awareness of the presence of perivascular spaces in a cohort of healthy adolescents provides the foundation for further research regarding the role of these structural variants in health and disease.
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U2 - 10.3174/ajnr.A6789
DO - 10.3174/ajnr.A6789
M3 - Article
C2 - 33033050
AN - SCOPUS:85096050003
VL - 41
SP - 2139
EP - 2145
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 11
ER -