Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity

Medicine & Life Sciences

• Loperamide 84%
• Temperature 41%
• Cardiotoxicity 11%
• Muscle Cells 9%
• Action Potentials 9%
• Bepridil 8%
• dofetilide 8%
• Sotalol 7%
• Torsades de Pointes 7%
• Quinidine 6%
• Pharmaceutical Preparations 6%
• Opioid Receptors 5%
• HEK293 Cells 5%
• Baths 5%
• Ion Channels 5%
• Computer Simulation 4%
• Diarrhea 4%
• Cell Line 3%
• Safety 3%
• In Vitro Techniques 2%
• Proteins 1%
• Therapeutics 1%

Chemical Compounds

• Block Like Crystal 39%
• Dofetilide 10%
• Bepridil 10%
• Sotalol 9%
• Dose 8%
• IC50 8%
• Quinidine 7%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 6%
• Drug 6%
• Safety 4%
• Protein 2%
• Ion 2%