Characterization of individual ultrasound microbubble dynamics with a light-scattering system

Mark J. Hsu, Mohammad Eghtedari, Andrew P. Goodwin, David J. Hall, Robert F. Mattrey, Sadik Esener

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

Original languageEnglish (US)
Article number067002
JournalJournal of Biomedical Optics
Volume16
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

payload delivery (STS)
Light scattering
light scattering
Ultrasonics
cycles
acoustic properties
image contrast
cavitation flow
Fourier transforms
Imaging techniques
formulations
Acoustic properties
oscillations
acoustics
Cavitation
Contrast Media
Acoustics

Keywords

  • acousto-optics
  • medical imaging
  • ultrasonics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Characterization of individual ultrasound microbubble dynamics with a light-scattering system. / Hsu, Mark J.; Eghtedari, Mohammad; Goodwin, Andrew P.; Hall, David J.; Mattrey, Robert F.; Esener, Sadik.

In: Journal of Biomedical Optics, Vol. 16, No. 6, 067002, 06.2011.

Research output: Contribution to journalArticle

Hsu, Mark J. ; Eghtedari, Mohammad ; Goodwin, Andrew P. ; Hall, David J. ; Mattrey, Robert F. ; Esener, Sadik. / Characterization of individual ultrasound microbubble dynamics with a light-scattering system. In: Journal of Biomedical Optics. 2011 ; Vol. 16, No. 6.
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