Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells

David M. Lewinsohn, Mark R. Alderson, Andria L. Briden, Stanley R. Riddell, Steven G. Reed, Kenneth H. Grabstein

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Previous studies in murine models, including those using the β2 microglobulin knockout mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response to tuberculosis. This report demonstrates the existence of human Mtb-reactive CD8+ T cells. These cells are present preferentially in persons infected with Mtb and produce interferon γ in response to stimulation with Mtb-infected target cells. Recognition of Mtb-infected cells by these CD8+ T cells is restricted neither by the major histocompatibility complex (MHC) class I A, B, or C alleles nor by CD1, although it is inhibited by anti-MHC class I antibody. The Mtb-specific CD8+ T cells recognize an antigen which is generated in the proteasome, but which does not require transport through the Golgi-ER. The data suggest the possible use of nonpolymorphic MHC class Ib antigen presenting structures other than CD1.

Original languageEnglish (US)
Pages (from-to)1633-1640
Number of pages8
JournalJournal of Experimental Medicine
Volume187
Issue number10
DOIs
StatePublished - May 18 1998

Keywords

  • Antigen presentation
  • CD8 lymphocytes
  • Interferon γ
  • Intracellular pathogens
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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