Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

N. L. Haigwood; L. Misher; S. M. Chin; M. Blair; V. Planelles; C. J. Scandella; K. S. Steimer; M. B. Gardner; T. Yilma; V. M. Hirsch

Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

N. L. Haigwood, L. Misher, S. M. Chin, M. Blair, V. Planelles, C. J. Scandella, K. S. Steimer, M. B. Gardner, T. Yilma, V. M. Hirsch

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

Original language	English (US)
Pages (from-to)	82-90
Number of pages	9
Journal	Journal of medical primatology
Volume	21
Issue number	2-3
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Cite this

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title = "Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.",

abstract = "Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.",

author = "Haigwood, {N. L.} and L. Misher and Chin, {S. M.} and M. Blair and V. Planelles and Scandella, {C. J.} and Steimer, {K. S.} and Gardner, {M. B.} and T. Yilma and Hirsch, {V. M.}",

year = "1992",

language = "English (US)",

volume = "21",

pages = "82--90",

journal = "Journal of medical primatology",

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T1 - Characterization of group specific antibodies in primates

T2 - studies with SIV envelope in macaques.

AU - Haigwood, N. L.

AU - Misher, L.

AU - Chin, S. M.

AU - Blair, M.

AU - Planelles, V.

AU - Scandella, C. J.

AU - Steimer, K. S.

AU - Gardner, M. B.

AU - Yilma, T.

AU - Hirsch, V. M.

PY - 1992

Y1 - 1992

N2 - Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

AB - Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

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AN - SCOPUS:0026819095

SN - 0047-2565

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JO - Journal of medical primatology

JF - Journal of medical primatology

IS - 2-3

ER -

Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

Abstract

ASJC Scopus subject areas

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