Characterization of complementary DNA encoding the precursor for gonadotropin-releasing hormone and its associated peptide from a teleost fish

Chris T. Bond, Richard C. Francis, Russell D. Fernald, John P. Adelman

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Reproductive maturity among male African cichlids Haplochromis burtoni is cued by a series of environmental and social interactions and is mediated physiologically by GnRH. A cDNA clone encoding the precursor for GnRH was isolated from this teleost. The molecular architecture of the predicted prohormone is analogous to that of the previously characterized mammalian forms; however, the predicted sequence of the associated peptide is strikingly different. Attempts to isolate a putative second precursor using low stringency hybridization were not successful despite evidence that a second related decapeptide exists in at least some teleost species.

Original languageEnglish (US)
Pages (from-to)931-937
Number of pages7
JournalMolecular Endocrinology
Volume5
Issue number7
DOIs
StatePublished - Jul 1 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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