Characterization of brain development in the ferret via MRI

Alan R. Barnette, Jeffery J. Neil, Christopher (Chris) Kroenke, Jennifer L. Griffith, Adrian A. Epstein, Philip V. Bayly, Andrew K. Knutsen, Terrie E. Inder

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Animal models with complex cortical development are useful for improving our understanding of the wide spectrum of neurodevelopmental challenges facing human preterm infants. MRI techniques can define both cerebral injury and alterations in cerebral development with translation between animal models and the human infant. We hypothesized that the immature ferret would display a similar sequence of brain development [both gray (GM) and white matter (WM)] to that of the preterm human infant. We describe postnatal ferret neurodevelopment with conventional and diffusion MRI. The ferret is born lissencephalic with a thin cortical plate and relatively large ventricles. Cortical folding and WM maturation take place during the first month of life. From the mid-second through the third week of postnatal life, the ferret brain undergoes a similar, though less complex, pattern of maturational changes to those observed in the human brain during the second half of gestation. GM anisotropy decreases rapidly in the first 3 wks of life, followed by an upward surge of surface folding and WM anisotropy over the next 2 wks.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalPediatric Research
Volume66
Issue number1
DOIs
StatePublished - Jul 2009

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Ferrets
Anisotropy
Brain
Premature Infants
Animal Models
Diffusion Magnetic Resonance Imaging
Cerebral Cortex
Pregnancy
Wounds and Injuries
White Matter

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Barnette, A. R., Neil, J. J., Kroenke, C. C., Griffith, J. L., Epstein, A. A., Bayly, P. V., ... Inder, T. E. (2009). Characterization of brain development in the ferret via MRI. Pediatric Research, 66(1), 80-84. https://doi.org/10.1203/PDR.0b013e3181a291d9

Characterization of brain development in the ferret via MRI. / Barnette, Alan R.; Neil, Jeffery J.; Kroenke, Christopher (Chris); Griffith, Jennifer L.; Epstein, Adrian A.; Bayly, Philip V.; Knutsen, Andrew K.; Inder, Terrie E.

In: Pediatric Research, Vol. 66, No. 1, 07.2009, p. 80-84.

Research output: Contribution to journalArticle

Barnette, AR, Neil, JJ, Kroenke, CC, Griffith, JL, Epstein, AA, Bayly, PV, Knutsen, AK & Inder, TE 2009, 'Characterization of brain development in the ferret via MRI', Pediatric Research, vol. 66, no. 1, pp. 80-84. https://doi.org/10.1203/PDR.0b013e3181a291d9
Barnette AR, Neil JJ, Kroenke CC, Griffith JL, Epstein AA, Bayly PV et al. Characterization of brain development in the ferret via MRI. Pediatric Research. 2009 Jul;66(1):80-84. https://doi.org/10.1203/PDR.0b013e3181a291d9
Barnette, Alan R. ; Neil, Jeffery J. ; Kroenke, Christopher (Chris) ; Griffith, Jennifer L. ; Epstein, Adrian A. ; Bayly, Philip V. ; Knutsen, Andrew K. ; Inder, Terrie E. / Characterization of brain development in the ferret via MRI. In: Pediatric Research. 2009 ; Vol. 66, No. 1. pp. 80-84.
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