Characterization of an EPSP-like potential recorded remotely from the round window

David F. Dolan, L. Lin Xi, Alfred L. Nuttall

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The whole-nerve cochlear action potential (CAP), to tone burst stimulation, was recorded before and after application of tetrodotoxin (TTX) to the intact round window (RW) membrane. TTX abolished the CAP leaving a residual negative potential without altering the summating potential (SP) or the cochlear microphonic (CM). The residual potential retained its polarity when recorded from scala vestibuli. The peak latency, amplitude, and tuning properties of the residual potential showed features similar to the CAP. Application of kainic acid to the RW membrane eliminated the residual potential, leaving the SP and CM unaltered. It is hypothesized that the sources of the residual potential are the excitatory post-synaptic potentials from the peripheral processes of afferent dendrites under the inner hair cells.

Original languageEnglish (US)
Pages (from-to)2167-2171
Number of pages5
JournalJournal of the Acoustical Society of America
Volume86
Issue number6
DOIs
StatePublished - Dec 1989

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics

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