Characterization of a murine gene expressed from the inactive X chromosome

Giuseppe Borsani, Rossana Tonlorenzi, M. Christine Simmler, Luisa Dandolo, Danielle Arnaud, Valeria Capra, Markus Grompe, Antonio Pizzuti, Donna Muzny, Charles Lawrence, Huntington F. Willard, Philip Avner, Andrea Ballabio

Research output: Contribution to journalArticlepeer-review

422 Scopus citations

Abstract

In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome1. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalNature
Volume351
Issue number6324
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • General

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