Characterisation of seven human ovarian tumour cell lines

A. P. Wilson, M. Dent, T. Pejovic, L. Hubbold, H. Radford

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Characteristics of a panel of seven human ovarian tumour cell lines are presented. Positive staining with HMFG2 and ultrastructural identification of desmosomes confirmed the epithelial nature of the cell lines. The lines showed wide variations in ploidy, doubling times and clonogenicity in soft agar. Both vimentin and keratin were equally expressed in five lines, one line showed strong preferential expression of keratin and one line showed preferential expression of vimentin. Karyotypic changes associated with ovarian cancer were identified in all the lines. Four of the seven cell lines showed loss of chromosome material distal to 11p13-15. These cell lines offer considerable potential for research into the biology and genetics of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)722-727
Number of pages6
JournalBritish Journal of Cancer
Volume74
Issue number5
DOIs
StatePublished - 1996

Keywords

  • Characterisation
  • Heterogeneity
  • Karyotype
  • Ovarian tumour line

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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