Abstract
5-Hydroxytryptamine (5-HT, serotonin) is an indolealkylamine that is found in multiple tissues of vertebrates and invertebrates. This chapter reviews the biochemistry, pharmacology, and physiology of 5-HT receptors. Each receptor subtype has a unique distribution. 5-HTIA receptors are located most densely in the limbic system, 5-HTIB in the striatum, 5-HTIC in the choroid plexus, 5-HT2 in the neocortex, and 5-HT3 in the area postrema. A consistently observed effect of 5-HTIA activation has been the modulation of adenylate cyclase activity. Both increases in basal cyclase and the inhibition of forskolin-stimulated cyclase activity have been reported. These discrepancies may have resulted from tissues that had more than one type of closely related 5-HT receptor. This problem has been surmounted by using mammalian cell lines that have no 5-HT receptors and transfecting them with the 5-HTIA gene.
Original language | English (US) |
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Pages (from-to) | 221-250 |
Number of pages | 30 |
Journal | New Comprehensive Biochemistry |
Volume | 24 |
Issue number | C |
DOIs | |
State | Published - Jan 1 1993 |
Keywords
- 1-(2,5,-dimethoxy-4-bromophenyl)-2-aminopropane (DOB)
- 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
- 1-(2-methoxyphenyl)4-[4-(2-phthalimido)butyI]piperazine(NAN-190)
- 1-(3-chlorophenyl)piperazine (mCPP)
- 1-(m-chloropheny1)-biguanide (mCBG)
- 1-(m-trifluoromethylphenyl)piperazine(TFMPP)
- 1-phenyl-biguanide (PBG)
- 5-carboxamidotryptamine (5-CT)
- 5-hydroxytryptamine (5-HT, serotonin)
- 5-hydroxytryptophan (5-HTP)
- 5-methoxytryptamine (5-MeOT)
- 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
- GR-38032F (odansetron)
- GTP-binding protein (G proteins)
- choroid plexus (CP)
- concentration causing 50% maximal effect (EC)
- diacylglycerol (DAG)
- dissociation constant (K)
- dorsal raphe (DR)
- hyperpolarization-activated current (I)
- inhibitory postsynaptic potential (IPSP)
- inositol-1,4,5-triphosphate (IP3)
- lysergic acid diethylamide (LSD)
- methylenedioxymethamphetamine (MDMA)
- monoamine oxidase (MAO)
- phosphatidylinositol (PI)
- phospolipase C (PLC)
- protein kinase C (PKC)
- slow excitatory postsynaptic potential (sEPSP)
- spiroperidol (spiperone)
ASJC Scopus subject areas
- Biochemistry