Chapter 1.3 Gene targeted animals with alterations in corticotropin pathways: new insights into allostatic control

Sarah C. Coste, Susan Murray, Mary Stenzel-Poore

Research output: Contribution to journalArticle

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Abstract

The corticotropin-releasing factor (CRF) family constitutes a primary system that mediates adaptive neuroendocrine, autonomic, and behavioral responses to stress, a process known as allostasis. Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways. A collection of models have been generated that harbor specific alterations in ligands, receptors, and the binding protein. In this review, we describe prominent neuroendocrine and behavioral features of these genetic mouse models that have led to new insights of allostatic regulation and associated pathology.

Original languageEnglish (US)
Pages (from-to)51-74
Number of pages24
JournalTechniques in the Behavioral and Neural Sciences
Volume15
Issue numberPART 2
DOIs
Publication statusPublished - 2005

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Keywords

  • α-GSU
  • ACTH
  • Adrenocorticotropin hormone
  • Arginine vasopression
  • AVP
  • Bed nucleus of the stria terminalis
  • BNST
  • Central nervous system
  • CNS
  • Corticotropin-releasing factor
  • CRF
  • CRF binding protein
  • CRF receptor type 1
  • CRF receptor type 2
  • CRF-BP
  • CRF
  • CRF
  • Glucocorticoid receptor
  • Glycoprotein hormone α-subunit
  • GR
  • HPA
  • Hypothalamic-pituitary-adrenal axis
  • icv
  • IL-6
  • Interleukin 6
  • Intracerebroventricular
  • Knockout
  • KO
  • Lipopolysaccharide
  • LPS
  • Metallothionein
  • Mineralocorticoid receptor
  • mMT
  • MR
  • NTS
  • Nucleus of the solitary tract
  • Paraventricular nucleus of the hypothalamus
  • Phenylethanolamine N-methyltransferase
  • PNMT
  • POMC
  • pro-opiomelanocortin
  • PVN
  • Tg
  • Transgenic
  • Ventromedial hypothalamus
  • VMH
  • Wild-type
  • WT
  • YAC
  • Yeast artificial chromosome

ASJC Scopus subject areas

  • Behavioral Neuroscience

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