Changes in the baroreflex during pregnancy in conscious dogs: Heart rate and hormonal responses

Virginia Brooks, Lanny C. Keil

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressures, heart rate, and plasma hormone concentrations during 30-min infusions of three doses of nitroprusside (1, 2, and 4 μg/kg · min). Between-group differences were determined by comparing the relationships between arterial or atrial pressure and plasma hormone concentrations. Hypotension induced increases in heart rate and plasma levels of vasopressin, ACTH, and cortisol were blunted when the dogs were pregnant. In contrast, reflex increases in PRA and angiotensin-II were increased. These results indicate that the activity of the baroreceptor reflex is altered during pregnancy in dogs.

Original languageEnglish (US)
Pages (from-to)1894-1901
Number of pages8
JournalEndocrinology
Volume135
Issue number5
DOIs
StatePublished - Nov 1994

Fingerprint

Baroreflex
Heart Rate
Dogs
Pregnancy
Atrial Pressure
Vasopressins
Angiotensin II
Adrenocorticotropic Hormone
Reflex
Hydrocortisone
Arterial Pressure
Controlled Hypotension
Hormones
Nitroprusside

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Changes in the baroreflex during pregnancy in conscious dogs : Heart rate and hormonal responses. / Brooks, Virginia; Keil, Lanny C.

In: Endocrinology, Vol. 135, No. 5, 11.1994, p. 1894-1901.

Research output: Contribution to journalArticle

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