TY - JOUR
T1 - Changes in the baroreflex during pregnancy in conscious dogs
T2 - Heart rate and hormonal responses
AU - Brooks, Virginia L.
AU - Keil, Lanny C.
PY - 1994/11
Y1 - 1994/11
N2 - This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressures, heart rate, and plasma hormone concentrations during 30-min infusions of three doses of nitroprusside (1, 2, and 4 μg/kg · min). Between-group differences were determined by comparing the relationships between arterial or atrial pressure and plasma hormone concentrations. Hypotension induced increases in heart rate and plasma levels of vasopressin, ACTH, and cortisol were blunted when the dogs were pregnant. In contrast, reflex increases in PRA and angiotensin-II were increased. These results indicate that the activity of the baroreceptor reflex is altered during pregnancy in dogs.
AB - This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressures, heart rate, and plasma hormone concentrations during 30-min infusions of three doses of nitroprusside (1, 2, and 4 μg/kg · min). Between-group differences were determined by comparing the relationships between arterial or atrial pressure and plasma hormone concentrations. Hypotension induced increases in heart rate and plasma levels of vasopressin, ACTH, and cortisol were blunted when the dogs were pregnant. In contrast, reflex increases in PRA and angiotensin-II were increased. These results indicate that the activity of the baroreceptor reflex is altered during pregnancy in dogs.
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U2 - 10.1210/endo.135.5.7956910
DO - 10.1210/endo.135.5.7956910
M3 - Article
C2 - 7956910
AN - SCOPUS:0028027957
SN - 0013-7227
VL - 135
SP - 1894
EP - 1901
JO - Endocrinology
JF - Endocrinology
IS - 5
ER -