Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves

Maros Ferencik, Linda A. Pape

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Bicuspid aortic valve (BAV) is associated with premature valve dysfunction and abnormalities of the ascending aorta. Limited data exist regarding serial changes of aortic dilation in patients with BAV. We studied paired transthoracic echocardiograms of 68 patients with BAV (mean age 44 years) and with at least 2 examinations >12 months apart (mean follow-up 47 months) to characterize the progression of aortic dilation and the natural history of valve function. We measured aortic root and ascending aortic diameters at baseline and follow-up. We measured aortic gradients and severity of aortic regurgitation (AR). During follow-up, aortic diameters increased at the sinuses of Valsalva by 1.9 mm (95% confidence interval [CI] 1.3 to 2.5), at the sinotubular junction by 1.6 mm (95% CI 0.8 to 2.3), and at the proximal ascending aorta by 2.7 mm (95% CI 1.9 to 3.6). Mean rate of diameter progression was 0.5 mm/year at the sinuses of Valsalva (95% CI 0.3 to 0.7), 0.5 mm/year at the sinotubular junction (95% CI 0.3 to 0.7), and 0.9 mm/year at the proximal ascending aorta (95% CI 0.6 to 1.2). Progression was observed regardless of hemodynamic function at baseline. Mean aortic valve gradient increased significantly from baseline to follow-up (17.6 mm Hg vs 25.7 mm Hg, p

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalAmerican Journal of Cardiology
Volume92
Issue number1
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

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Aortic Valve
Aorta
Confidence Intervals
Sinus of Valsalva
Dilatation
Aortic Valve Insufficiency
Natural History
Bicuspid Aortic Valve
Hemodynamics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves. / Ferencik, Maros; Pape, Linda A.

In: American Journal of Cardiology, Vol. 92, No. 1, 01.07.2003, p. 43-46.

Research output: Contribution to journalArticle

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