Changes in serum sex steroid levels during megestrol acetate therapy

R. F. Pommier, E. A. Woltering, W. S. Fletcher

    Research output: Contribution to journalArticle

    5 Scopus citations

    Abstract

    We hypothesized that megestrol acetate (MA) may work on breast carcinoma by inducing changes in serum sex steroid levels. We prospectively measured levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone (DHEA), estrone (E1), and estradiol (E2) in 18 postmenopausal women before and during megestrol acetate therapy. MA significantly suppressed serum FSH, LH, DHEA and E1 levels. However, this was accompanied by a marked increase in serum E2 levels as measured by radioimmunoassay performed on whole serum. MA did not cross-react with the anti-E2 antibodies used in the assay. Elevated E2 levels also occurred in oophorectomized and/or adrenalectomized patients indicating the ovary and adrenal are not the source of the elevated E2 levels. We conclude that MA may be metabolized to oestrogenic compounds that crossreact with antibodies to E2, explaining the elevated E2 levels observed. The effects of these oestrogenic metabolites on breast carcinoma are unknown.

    Original languageEnglish (US)
    Pages (from-to)351-359
    Number of pages9
    JournalSurgical Oncology
    Volume3
    Issue number6
    DOIs
    StatePublished - Dec 1994

    Keywords

    • breast neoplasms
    • hormone therapy
    • megestrol acetate
    • neuroendocrine axis
    • radioimmunoassay
    • sex steroids

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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