Changes in protein kinase C activities are correlated with the metaplastic transformation of Schwann cell precursors of avian embryos into melanocytes

L. Hess, T. Chamberlin, Gary Ciment

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In previous work, we found that the phorbol ester drug 12-0-tetradecanoyl phorbol acetate (TPA) reverses the development restriction of melanogenesis that occurs early in neural crest development, causing Schwann cell precursors to undergo a metaplastic transformation into melanocytes. In this study, we examine whether these effects of TPA may be mediated by changes in endogenous levels of protein kinase C (PKC) activities. We report that low levels of PKC activity are correlated with this adventitious pigmentation in the crest-derived cells of dorsal root ganglia both during normal development and following TPA treatment in culture. These results suggest that regulation of endogenous levels of PKC plays a role in developmental decisions that neural crest cells make during early embryogenesis.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of Neuroscience Research
Volume21
Issue number2-4
StatePublished - 1988

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Melanocytes
Schwann Cells
Protein Kinase C
Acetates
Embryonic Structures
Neural Crest
Pigmentation
Spinal Ganglia
Phorbol Esters
Embryonic Development
Pharmaceutical Preparations
phorbol

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Changes in protein kinase C activities are correlated with the metaplastic transformation of Schwann cell precursors of avian embryos into melanocytes. / Hess, L.; Chamberlin, T.; Ciment, Gary.

In: Journal of Neuroscience Research, Vol. 21, No. 2-4, 1988, p. 101-106.

Research output: Contribution to journalArticle

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