Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina

Robert M. Duvoisin; Congxiao Zhang; Dânia E. Hamassaki-Britto; Luiz R.G. Britto

doi:10.1016/0304-3940(94)11120-8

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina

Robert M. Duvoisin, Congxiao Zhang, Dânia E. Hamassaki-Britto, Luiz R.G. Britto

Physiology & Pharmacology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.

Original language	English (US)
Pages (from-to)	83-86
Number of pages	4
Journal	Neuroscience Letters
Volume	183
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)11120-8
State	Published - Jan 2 1995

Keywords

Glutamate receptor
In situ hybridization
Kainate
Photoreceptor degeneration
Retina
rd mouse
α-Andno-3-hydroxy-5-methyl-isoxasole-4-propionate

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)11120-8

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title = "Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina",

abstract = "The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.",

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AU - Britto, Luiz R.G.

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