Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina

Robert Duvoisin, Congxiao Zhang, Dânia E. Hamassaki-Britto, Luiz R G Britto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalNeuroscience Letters
Volume183
Issue number1-2
DOIs
StatePublished - Jan 2 1995
Externally publishedYes

Fingerprint

Kainic Acid Receptors
Propionates
Glutamate Receptors
Retina
Photoreceptor Cells
Retinal Degeneration
In Situ Hybridization
Genes

Keywords

  • Glutamate receptor
  • In situ hybridization
  • Kainate
  • Photoreceptor degeneration
  • rd mouse
  • Retina
  • α-Andno-3-hydroxy-5-methyl-isoxasole-4-propionate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. / Duvoisin, Robert; Zhang, Congxiao; Hamassaki-Britto, Dânia E.; Britto, Luiz R G.

In: Neuroscience Letters, Vol. 183, No. 1-2, 02.01.1995, p. 83-86.

Research output: Contribution to journalArticle

Duvoisin, Robert ; Zhang, Congxiao ; Hamassaki-Britto, Dânia E. ; Britto, Luiz R G. / Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. In: Neuroscience Letters. 1995 ; Vol. 183, No. 1-2. pp. 83-86.
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