Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina

Robert M. Duvoisin, Congxiao Zhang, Dânia E. Hamassaki-Britto, Luiz R.G. Britto

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalNeuroscience Letters
Volume183
Issue number1-2
DOIs
StatePublished - Jan 2 1995

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Keywords

  • Glutamate receptor
  • In situ hybridization
  • Kainate
  • Photoreceptor degeneration
  • Retina
  • rd mouse
  • α-Andno-3-hydroxy-5-methyl-isoxasole-4-propionate

ASJC Scopus subject areas

  • Neuroscience(all)

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