Abstract
The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-86 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 183 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 2 1995 |
| Externally published | Yes |
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Keywords
- Glutamate receptor
- In situ hybridization
- Kainate
- Photoreceptor degeneration
- rd mouse
- Retina
- α-Andno-3-hydroxy-5-methyl-isoxasole-4-propionate
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. / Duvoisin, Robert; Zhang, Congxiao; Hamassaki-Britto, Dânia E.; Britto, Luiz R G.
In: Neuroscience Letters, Vol. 183, No. 1-2, 02.01.1995, p. 83-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina
AU - Duvoisin, Robert
AU - Zhang, Congxiao
AU - Hamassaki-Britto, Dânia E.
AU - Britto, Luiz R G
PY - 1995/1/2
Y1 - 1995/1/2
N2 - The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
AB - The effects of photoreceptor cell degeneration on the expression of nine α-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
KW - Glutamate receptor
KW - In situ hybridization
KW - Kainate
KW - Photoreceptor degeneration
KW - rd mouse
KW - Retina
KW - α-Andno-3-hydroxy-5-methyl-isoxasole-4-propionate
UR - http://www.scopus.com/inward/record.url?scp=0028796886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028796886&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)11120-8
DO - 10.1016/0304-3940(94)11120-8
M3 - Article
VL - 183
SP - 83
EP - 86
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -