Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation

Amanda K. Hurliman, Leon Speroff, Richard Stouffer, Phillip Patton, Annette Lee, Theodore A. Molskness

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To determine whether angiopoietin (ANGPT)-1 and -2 are detectable in the circulation of nonhuman primates and women and whether these levels fluctuate in association with ovarian activity. Design: Prospective. Setting: National Primate Research Center, medical center, and infertility clinic. Patient(s): Adult female rhesus monkeys; 15 women donating oocytes for infertility treatment. Intervention(s): Controlled ovarian stimulation with gonadotropins, removal of the corpus luteum and ovaries, oocyte retrieval, and ET. Main Outcome Measure(s): Circulating levels of ANGPT-1 and ANGPT-2. Result(s): Serum ANGPT-1 and ANGPT-2 levels were detectable and invariant in maintaining an ANGPT-1 to -2 ratio >1 in [1] macaques over the course of the natural menstrual cycle, during a controlled ovulation protocol, and after removal of the corpus luteum or ovaries and [2] women undergoing controlled ovarian simulation. In contrast, the ANGPT-1 to -2 ratio was markedly decreased (

Original languageEnglish (US)
Pages (from-to)1493-1499
Number of pages7
JournalFertility and Sterility
Volume93
Issue number5
DOIs
StatePublished - Mar 15 2010

Fingerprint

Angiopoietins
Angiopoietin-1
Ovulation Induction
Menstrual Cycle
Angiopoietin-2
Pregnancy
Corpus Luteum
Infertility
Primates
Ovary
Oocyte Retrieval
Macaca
Ovulation
Macaca mulatta
Gonadotropins
Oocytes
Biomedical Research
Outcome Assessment (Health Care)
Serum

Keywords

  • angiogenesis
  • Angiopoietin-1
  • angiopoietin-2
  • ovarian hyperstimulation syndrome (OHSS)
  • vascular permeability

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation. / Hurliman, Amanda K.; Speroff, Leon; Stouffer, Richard; Patton, Phillip; Lee, Annette; Molskness, Theodore A.

In: Fertility and Sterility, Vol. 93, No. 5, 15.03.2010, p. 1493-1499.

Research output: Contribution to journalArticle

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