TY - JOUR
T1 - Changes in cerebrospinal fluid and plasma amino acid concentrations with elevated dietary protein concentration in dogs with portacaval shunts
AU - Schaeffer, Monica C.
AU - Rogers, Quinton R.
AU - Leung, Philip M.B.
AU - Wolfe, Bruce M.
AU - Strombeck, Donald R.
PY - 1991
Y1 - 1991
N2 - Effects of dietary protein concentration on plasma and cerebrospinal fluid (CSF) amino acids (AA) in dogs with portacaval shunts (PCS) were examined. An 18% protein purified diet (18P) was fed to 4 PCS dogs and 2 controls; at week 10, 2 of the PCS dogs were switched to 36% protein (36P) until week 28. Effects of the diet switch on plasma and CSF AA in 8 normal dogs were determined in another experiment. Neither surgery nor protein level significantly affected average food intake (weeks 10-28). Plasma amino acid patterns typical of PCS animals were observed: phenylalanine and tyrosine increased and branched chain AA decreased with shunting (p<0.05). Plasma phenylalanine increased further with 36P in PCS dogs (p<0.05), but was not affected by dietary protein concentration in controls. With 36P: CSF arginine, serine, histidine, tryptophan, phenylalanine, glutamate and glutamine increased in PCS dogs; but only arginine decreased in CSF of controls (p<0.05). In PCS dogs, significant CSF AA changes with elevated dietary protein were unrelated to plasma AA changes.
AB - Effects of dietary protein concentration on plasma and cerebrospinal fluid (CSF) amino acids (AA) in dogs with portacaval shunts (PCS) were examined. An 18% protein purified diet (18P) was fed to 4 PCS dogs and 2 controls; at week 10, 2 of the PCS dogs were switched to 36% protein (36P) until week 28. Effects of the diet switch on plasma and CSF AA in 8 normal dogs were determined in another experiment. Neither surgery nor protein level significantly affected average food intake (weeks 10-28). Plasma amino acid patterns typical of PCS animals were observed: phenylalanine and tyrosine increased and branched chain AA decreased with shunting (p<0.05). Plasma phenylalanine increased further with 36P in PCS dogs (p<0.05), but was not affected by dietary protein concentration in controls. With 36P: CSF arginine, serine, histidine, tryptophan, phenylalanine, glutamate and glutamine increased in PCS dogs; but only arginine decreased in CSF of controls (p<0.05). In PCS dogs, significant CSF AA changes with elevated dietary protein were unrelated to plasma AA changes.
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U2 - 10.1016/0024-3205(91)90335-9
DO - 10.1016/0024-3205(91)90335-9
M3 - Article
C2 - 2046453
AN - SCOPUS:0025729104
SN - 0024-3205
VL - 48
SP - 2215
EP - 2223
JO - Life Sciences
JF - Life Sciences
IS - 23
ER -