Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)

D. A. Smucny, D. B. Allison, D. K. Ingram, G. S. Roth, J. W. Kemnitz, Steven Kohama, M. A. Lane

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Identifying changes with age in physiological variables of captive nonhuman primates will aid in the proper treatment and clinical diagnosis of these animals, as well as enhance our understanding of nonhuman primate models for human aging. Information for 33 physiological variables was obtained from the Primate Aging Database, a multi-centered database being developed for clinical and research use. Using multiple regression analyses, we investigated the relationship of age to hematological variables, blood chemistry and body weight in 345 captive rhesus monkeys (age range 7-30 years) from three different primate research facilities. The analyses revealed that 15 of these variables show a significant relationship with chronological age and are altered in older as compared with adult animals. Here we present the first phase of a project that will: a) identify changes with age in physiological variables among adult captive rhesus macaques; and b) characterize normative values for the aging rhesus population.

Original languageEnglish (US)
Pages (from-to)161-173
Number of pages13
JournalJournal of Medical Primatology
Volume30
Issue number3
StatePublished - 2001
Externally publishedYes

Fingerprint

blood chemistry
Hematology
hematology
Macaca mulatta
Primates
Databases
research facilities
Research
Body Weight
Regression Analysis
animal models
body weight
Population
animals

Keywords

  • Age effects
  • Monkeys
  • Veterinary care of older primates

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Smucny, D. A., Allison, D. B., Ingram, D. K., Roth, G. S., Kemnitz, J. W., Kohama, S., & Lane, M. A. (2001). Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). Journal of Medical Primatology, 30(3), 161-173.

Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). / Smucny, D. A.; Allison, D. B.; Ingram, D. K.; Roth, G. S.; Kemnitz, J. W.; Kohama, Steven; Lane, M. A.

In: Journal of Medical Primatology, Vol. 30, No. 3, 2001, p. 161-173.

Research output: Contribution to journalArticle

Smucny, DA, Allison, DB, Ingram, DK, Roth, GS, Kemnitz, JW, Kohama, S & Lane, MA 2001, 'Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)', Journal of Medical Primatology, vol. 30, no. 3, pp. 161-173.
Smucny DA, Allison DB, Ingram DK, Roth GS, Kemnitz JW, Kohama S et al. Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). Journal of Medical Primatology. 2001;30(3):161-173.
Smucny, D. A. ; Allison, D. B. ; Ingram, D. K. ; Roth, G. S. ; Kemnitz, J. W. ; Kohama, Steven ; Lane, M. A. / Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). In: Journal of Medical Primatology. 2001 ; Vol. 30, No. 3. pp. 161-173.
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