CHANCE: Comprehensive software for quality control andvalidation of ChIP-seq data

35 Scopus citations

Abstract

ChIP-seq is a powerful method for obtaining genome-wide maps of protein-DNA interactions and epigeneticmodications. CHANCE (CHip-seq ANalytics and Condence Estimation) is a standalone package for ChIP-seqquality control and protocol optimization. Our user-friendly graphical software quickly estimates the strengthand quality of immunoprecipitations, identies biases, compares the user's data with ENCODE's large collectionof published datasets, performs multi-sample normalization, checks against qPCR-validated control regions, andproduces informative graphical reports. CHANCE is available at https://github.com/songlab/chance.

Original languageEnglish (US)
JournalGenome Biology
DOIs
Publication statusAccepted/In press - Oct 15 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

CHANCE : Comprehensive software for quality control andvalidation of ChIP-seq data. / Diaz, Aaron; Nellore, Abhinav; Song, Jun S.

In: Genome Biology, 15.10.2012.

Research output: Contribution to journalArticle