Challenges in using nonrandomized studies in systematic reviews of treatment interventions

Susan L. Norris, David Atkins

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Randomized, controlled trials (RCTs) are firmly established as the standard for determining which medical treatments are effective. In some areas of health care, however, among them surgery, public health, and the organization of health care delivery, most evidence addressing the effectiveness of clinical or policy interventions rests on nonrandomized studies. We examine the use of study designs other than RCTs in Evidence-based Practice Center reports addressing questions of the effectiveness of treatment interventions. These reports offer the opportunity to examine the approaches used and the challenges faced by reviewers when nonrandomized studies are included and their quality assessed. We then offer recommendations for using these studies in systematic reviews of treatment interventions.

Original languageEnglish (US)
Pages (from-to)1112-1119
Number of pages8
JournalAnnals of internal medicine
Issue number12 II
StatePublished - Jun 21 2005

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Challenges in using nonrandomized studies in systematic reviews of treatment interventions'. Together they form a unique fingerprint.

Cite this