Challenges and potential for ovarian preservation with SERMs

Alison Y. Ting, Brian K. Petroff

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Tamoxifen (TAM) is a selective estrogen receptor modulator with tissue-specific effects on estrogen signaling used predominantly for treatment and chemoprevention of breast cancers. Recent studies have shown that TAM prevents infertility and decreases follicular loss from common cancer chemotherapy and radiation therapy in preclinical models. Here we review current and novel uses of selective estrogen receptor modulator s and advantages and challenges for translation of TAM for human fertility preservation.

Original languageEnglish (US)
Article number133
JournalBiology of reproduction
Volume92
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Cancer
  • Fertility
  • Ovary
  • SERM
  • Tamoxifen

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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