Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: Priorities of the westhafen intercontinental group

Rudolph Kirk R Schultz, Kevin Scott Baker, Jaap J. Boelens, Catherine M. Bollard, R. Maarten Egeler, Mort Cowan, Ruth Ladenstein, Arjan Lankester, Franco Locatelli, Anita Lawitschka, John E. Levine, Mignon Loh, Eneida Nemecek, Charlotte Niemeyer, Vinod K. Prasad, Vanderson Rocha, Shalini Shenoy, Brigitte Strahm, Paul Veys, Donna WallPeter Bader, Stephan A. Grupp, Michael A. Pulsipher, Christina Peters

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.

Original languageEnglish (US)
Pages (from-to)1279-1287
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume19
Issue number9
DOIs
StatePublished - 2013

Fingerprint

Cell Transplantation
Pediatrics
Bone Marrow
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation
Berlin
Blood Group Antigens
Germany
Transplantation
Clinical Trials
Transplants

Keywords

  • Hematopoietic cell
  • Pediatrics
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Hematology
  • Medicine(all)

Cite this

Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation : Priorities of the westhafen intercontinental group. / Schultz, Rudolph Kirk R; Baker, Kevin Scott; Boelens, Jaap J.; Bollard, Catherine M.; Egeler, R. Maarten; Cowan, Mort; Ladenstein, Ruth; Lankester, Arjan; Locatelli, Franco; Lawitschka, Anita; Levine, John E.; Loh, Mignon; Nemecek, Eneida; Niemeyer, Charlotte; Prasad, Vinod K.; Rocha, Vanderson; Shenoy, Shalini; Strahm, Brigitte; Veys, Paul; Wall, Donna; Bader, Peter; Grupp, Stephan A.; Pulsipher, Michael A.; Peters, Christina.

In: Biology of Blood and Marrow Transplantation, Vol. 19, No. 9, 2013, p. 1279-1287.

Research output: Contribution to journalArticle

Schultz, RKR, Baker, KS, Boelens, JJ, Bollard, CM, Egeler, RM, Cowan, M, Ladenstein, R, Lankester, A, Locatelli, F, Lawitschka, A, Levine, JE, Loh, M, Nemecek, E, Niemeyer, C, Prasad, VK, Rocha, V, Shenoy, S, Strahm, B, Veys, P, Wall, D, Bader, P, Grupp, SA, Pulsipher, MA & Peters, C 2013, 'Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: Priorities of the westhafen intercontinental group', Biology of Blood and Marrow Transplantation, vol. 19, no. 9, pp. 1279-1287. https://doi.org/10.1016/j.bbmt.2013.07.006
Schultz, Rudolph Kirk R ; Baker, Kevin Scott ; Boelens, Jaap J. ; Bollard, Catherine M. ; Egeler, R. Maarten ; Cowan, Mort ; Ladenstein, Ruth ; Lankester, Arjan ; Locatelli, Franco ; Lawitschka, Anita ; Levine, John E. ; Loh, Mignon ; Nemecek, Eneida ; Niemeyer, Charlotte ; Prasad, Vinod K. ; Rocha, Vanderson ; Shenoy, Shalini ; Strahm, Brigitte ; Veys, Paul ; Wall, Donna ; Bader, Peter ; Grupp, Stephan A. ; Pulsipher, Michael A. ; Peters, Christina. / Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation : Priorities of the westhafen intercontinental group. In: Biology of Blood and Marrow Transplantation. 2013 ; Vol. 19, No. 9. pp. 1279-1287.
@article{1c5bac03c25549e2bc7bcd078115cd94,
title = "Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: Priorities of the westhafen intercontinental group",
abstract = "More than 20{\%} of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.",
keywords = "Hematopoietic cell, Pediatrics, Transplantation",
author = "Schultz, {Rudolph Kirk R} and Baker, {Kevin Scott} and Boelens, {Jaap J.} and Bollard, {Catherine M.} and Egeler, {R. Maarten} and Mort Cowan and Ruth Ladenstein and Arjan Lankester and Franco Locatelli and Anita Lawitschka and Levine, {John E.} and Mignon Loh and Eneida Nemecek and Charlotte Niemeyer and Prasad, {Vinod K.} and Vanderson Rocha and Shalini Shenoy and Brigitte Strahm and Paul Veys and Donna Wall and Peter Bader and Grupp, {Stephan A.} and Pulsipher, {Michael A.} and Christina Peters",
year = "2013",
doi = "10.1016/j.bbmt.2013.07.006",
language = "English (US)",
volume = "19",
pages = "1279--1287",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation

T2 - Priorities of the westhafen intercontinental group

AU - Schultz, Rudolph Kirk R

AU - Baker, Kevin Scott

AU - Boelens, Jaap J.

AU - Bollard, Catherine M.

AU - Egeler, R. Maarten

AU - Cowan, Mort

AU - Ladenstein, Ruth

AU - Lankester, Arjan

AU - Locatelli, Franco

AU - Lawitschka, Anita

AU - Levine, John E.

AU - Loh, Mignon

AU - Nemecek, Eneida

AU - Niemeyer, Charlotte

AU - Prasad, Vinod K.

AU - Rocha, Vanderson

AU - Shenoy, Shalini

AU - Strahm, Brigitte

AU - Veys, Paul

AU - Wall, Donna

AU - Bader, Peter

AU - Grupp, Stephan A.

AU - Pulsipher, Michael A.

AU - Peters, Christina

PY - 2013

Y1 - 2013

N2 - More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.

AB - More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.

KW - Hematopoietic cell

KW - Pediatrics

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=84882769095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882769095&partnerID=8YFLogxK

U2 - 10.1016/j.bbmt.2013.07.006

DO - 10.1016/j.bbmt.2013.07.006

M3 - Article

C2 - 23883618

AN - SCOPUS:84882769095

VL - 19

SP - 1279

EP - 1287

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

IS - 9

ER -