CFTR: Mechanism of anion conduction

David C. Dawson, Stephen S. Smith, Monique K. Mansoura

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

The purpose of this review is to collect together the results of recent investigations of anion conductance by the cystic fibrosis transmembrane conductance regulator along with some of the basic background that is a prerequisite for developing some physical picture of the conduction process. The review begins with an introduction to the concepts of permeability and conductance and the Nernst-Planck and rate theory models that are used to interpret these parameters. Some of the physical forces that impinge on anion conductance are considered in the context of permeability selectivity and anion binding to proteins. Probes of the conduction process are considered, particularly permeant anions that bind tightly within the pore and block anion flow. Finally, structure-function studies are reviewed in the context of some predictions for the origin of pore properties.

Original languageEnglish (US)
Pages (from-to)S47-S75
JournalPhysiological Reviews
Volume79
Issue number1 SUPPL. 1
DOIs
StatePublished - Jan 1999

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Dawson, D. C., Smith, S. S., & Mansoura, M. K. (1999). CFTR: Mechanism of anion conduction. Physiological Reviews, 79(1 SUPPL. 1), S47-S75. https://doi.org/10.1152/physrev.1999.79.1.S47