Cerebrovascular biology and the various neural barriers: Challenges and future directions

Edward A. Neuwelt; N. Joan Abbott; Lester Drewes; Quentin R. Smith; Pierre O. Couraud; E. Antonio Chiocca; Kenneth L. Audus; Nigel H. Greig; Nancy D. Doolittle

doi:10.1097/00006123-199903000-00095

Cerebrovascular biology and the various neural barriers: Challenges and future directions

Edward A. Neuwelt, N. Joan Abbott, Lester Drewes, Quentin R. Smith, Pierre O. Couraud, E. Antonio Chiocca, Kenneth L. Audus, Nigel H. Greig, Nancy D. Doolittle

Neurology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

DESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment of brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified.

Original language	English (US)
Pages (from-to)	604-609
Number of pages	6
Journal	Neurosurgery
Volume	44
Issue number	3
DOIs	https://doi.org/10.1097/00006123-199903000-00095
State	Published - Mar 1999

Keywords

Blood-brain barrier
Cerebrovascular biology
Neural barriers

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1097/00006123-199903000-00095

Cite this

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title = "Cerebrovascular biology and the various neural barriers: Challenges and future directions",

abstract = "DESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment of brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified.",

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AU - Neuwelt, Edward A.

AU - Abbott, N. Joan

AU - Drewes, Lester

AU - Smith, Quentin R.

AU - Couraud, Pierre O.

AU - Chiocca, E. Antonio

AU - Audus, Kenneth L.

AU - Greig, Nigel H.

AU - Doolittle, Nancy D.

PY - 1999/3

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AB - DESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment of brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified.

KW - Blood-brain barrier

KW - Cerebrovascular biology

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Cerebrovascular biology and the various neural barriers: Challenges and future directions

Abstract

Keywords

ASJC Scopus subject areas

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