Cerebrovascular biology and the various neural barriers: Challenges and future directions

Edward A. Neuwelt, N. Joan Abbott, Lester Drewes, Quentin R. Smith, Pierre O. Couraud, E. Antonio Chiocca, Kenneth L. Audus, Nigel H. Greig, Nancy D. Doolittle

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

DESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment of brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified.

Original languageEnglish (US)
Pages (from-to)604-609
Number of pages6
JournalNeurosurgery
Volume44
Issue number3
StatePublished - Mar 1 1999

Keywords

  • Blood-brain barrier
  • Cerebrovascular biology
  • Neural barriers

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Neuwelt, E. A., Abbott, N. J., Drewes, L., Smith, Q. R., Couraud, P. O., Chiocca, E. A., Audus, K. L., Greig, N. H., & Doolittle, N. D. (1999). Cerebrovascular biology and the various neural barriers: Challenges and future directions. Neurosurgery, 44(3), 604-609.