Cerebrospinal fluid of parkinson's disease patients inhibits the growth and function of dopaminergic neurons in culture

Ruyi Hao, Robert B. Norgren, Yuen Sum Lau, Ronald F. Pfeiffer

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Article abstract-We report the possible existence of an inhibitory factor in the CSF of Parkinson's disease patients that inhibits the function and growth of dopaminergic neurons in rat mesencephalic culture. After 40 hours' exposure to the <10 kd fraction of CSF from PD patients, the high-affinity dopamine uptake was 66% of that of cultures exposed to CSF from controls. However, the number of dopaminergic neurons remained unchanged at this time. After 90 hours' exposure to the <10 kd fraction of CSF from PD patients, the number of dopaminergic neurons decreased to 10% of that in cultures exposed to CSF from controls, and the size of the remaining dopaminergic neurons in the culture became smaller. This inhibitory factor did not affect the growth of other types of neurons. The chemical nature of this inhibitory factor is under investigation.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalNeurology
Volume45
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Clinical Neurology

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