Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.

B. S. Richardson, Alan (Roger) Hohimer, J. M. Bissonnette, C. M. Machida

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To investigate the mechanism whereby glucose affects fetal breathing movements (FBM), cerebral metabolism was studied in 12 unanesthetized fetal lambs, during fasting-induced hypoglycemia and after a subsequent fetal infusion of glucose. Preductal arterial and sagittal sinus blood samples were analyzed for glucose and oxygen concentrations and for blood gases and pH. Measurements of regional brain blood flow were made with radioactive microspheres. Maternal fasting of 24- to 36-h duration resulted in a decrease in fetal blood glucose from 1.061 +/- 0.085 mmol X l-1 to 0.664 +/- 0.053 (P less than 0.001). Although cerebral glucose and O2 uptake remained unchanged, sagittal sinus CO2 partial pressure (Pco2) and [H+] were significantly decreased and may have contributed to the observed decrease in FBM. A 2-h infusion of glucose to the fetuses of fasted animals resulted in an increase in blood glucose to 2.452 +/- 0.173 mmol X l-1. Cerebral O2 consumption was again unchanged; however, cerebral glucose consumption was significantly increased as were sagittal sinus Pco2 and [H+], which may have contributed to the observed increase in FBM. These findings are consistent with the hypothesis that glucose affects the incidence of FBM in part by altering the environment of central chemoreceptors.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume245
Issue number5 Pt 1
StatePublished - Nov 1983

Fingerprint

Hypoglycemic Agents
Fetal Movement
Glucose
Respiration
Blood Glucose
Partial Pressure
Regional Blood Flow
Fetal Blood
Microspheres
Hypoglycemia
Fasting
Fetus
Gases
Mothers
Oxygen
Incidence
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Richardson, B. S., Hohimer, A. R., Bissonnette, J. M., & Machida, C. M. (1983). Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs. The American journal of physiology, 245(5 Pt 1).

Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs. / Richardson, B. S.; Hohimer, Alan (Roger); Bissonnette, J. M.; Machida, C. M.

In: The American journal of physiology, Vol. 245, No. 5 Pt 1, 11.1983.

Research output: Contribution to journalArticle

Richardson, BS, Hohimer, AR, Bissonnette, JM & Machida, CM 1983, 'Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.', The American journal of physiology, vol. 245, no. 5 Pt 1.
Richardson BS, Hohimer AR, Bissonnette JM, Machida CM. Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs. The American journal of physiology. 1983 Nov;245(5 Pt 1).
Richardson, B. S. ; Hohimer, Alan (Roger) ; Bissonnette, J. M. ; Machida, C. M. / Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs. In: The American journal of physiology. 1983 ; Vol. 245, No. 5 Pt 1.
@article{f7a5218bb6df46a38772b6c939f35475,
title = "Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.",
abstract = "To investigate the mechanism whereby glucose affects fetal breathing movements (FBM), cerebral metabolism was studied in 12 unanesthetized fetal lambs, during fasting-induced hypoglycemia and after a subsequent fetal infusion of glucose. Preductal arterial and sagittal sinus blood samples were analyzed for glucose and oxygen concentrations and for blood gases and pH. Measurements of regional brain blood flow were made with radioactive microspheres. Maternal fasting of 24- to 36-h duration resulted in a decrease in fetal blood glucose from 1.061 +/- 0.085 mmol X l-1 to 0.664 +/- 0.053 (P less than 0.001). Although cerebral glucose and O2 uptake remained unchanged, sagittal sinus CO2 partial pressure (Pco2) and [H+] were significantly decreased and may have contributed to the observed decrease in FBM. A 2-h infusion of glucose to the fetuses of fasted animals resulted in an increase in blood glucose to 2.452 +/- 0.173 mmol X l-1. Cerebral O2 consumption was again unchanged; however, cerebral glucose consumption was significantly increased as were sagittal sinus Pco2 and [H+], which may have contributed to the observed increase in FBM. These findings are consistent with the hypothesis that glucose affects the incidence of FBM in part by altering the environment of central chemoreceptors.",
author = "Richardson, {B. S.} and Hohimer, {Alan (Roger)} and Bissonnette, {J. M.} and Machida, {C. M.}",
year = "1983",
month = "11",
language = "English (US)",
volume = "245",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "5 Pt 1",

}

TY - JOUR

T1 - Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.

AU - Richardson, B. S.

AU - Hohimer, Alan (Roger)

AU - Bissonnette, J. M.

AU - Machida, C. M.

PY - 1983/11

Y1 - 1983/11

N2 - To investigate the mechanism whereby glucose affects fetal breathing movements (FBM), cerebral metabolism was studied in 12 unanesthetized fetal lambs, during fasting-induced hypoglycemia and after a subsequent fetal infusion of glucose. Preductal arterial and sagittal sinus blood samples were analyzed for glucose and oxygen concentrations and for blood gases and pH. Measurements of regional brain blood flow were made with radioactive microspheres. Maternal fasting of 24- to 36-h duration resulted in a decrease in fetal blood glucose from 1.061 +/- 0.085 mmol X l-1 to 0.664 +/- 0.053 (P less than 0.001). Although cerebral glucose and O2 uptake remained unchanged, sagittal sinus CO2 partial pressure (Pco2) and [H+] were significantly decreased and may have contributed to the observed decrease in FBM. A 2-h infusion of glucose to the fetuses of fasted animals resulted in an increase in blood glucose to 2.452 +/- 0.173 mmol X l-1. Cerebral O2 consumption was again unchanged; however, cerebral glucose consumption was significantly increased as were sagittal sinus Pco2 and [H+], which may have contributed to the observed increase in FBM. These findings are consistent with the hypothesis that glucose affects the incidence of FBM in part by altering the environment of central chemoreceptors.

AB - To investigate the mechanism whereby glucose affects fetal breathing movements (FBM), cerebral metabolism was studied in 12 unanesthetized fetal lambs, during fasting-induced hypoglycemia and after a subsequent fetal infusion of glucose. Preductal arterial and sagittal sinus blood samples were analyzed for glucose and oxygen concentrations and for blood gases and pH. Measurements of regional brain blood flow were made with radioactive microspheres. Maternal fasting of 24- to 36-h duration resulted in a decrease in fetal blood glucose from 1.061 +/- 0.085 mmol X l-1 to 0.664 +/- 0.053 (P less than 0.001). Although cerebral glucose and O2 uptake remained unchanged, sagittal sinus CO2 partial pressure (Pco2) and [H+] were significantly decreased and may have contributed to the observed decrease in FBM. A 2-h infusion of glucose to the fetuses of fasted animals resulted in an increase in blood glucose to 2.452 +/- 0.173 mmol X l-1. Cerebral O2 consumption was again unchanged; however, cerebral glucose consumption was significantly increased as were sagittal sinus Pco2 and [H+], which may have contributed to the observed increase in FBM. These findings are consistent with the hypothesis that glucose affects the incidence of FBM in part by altering the environment of central chemoreceptors.

UR - http://www.scopus.com/inward/record.url?scp=0020858791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020858791&partnerID=8YFLogxK

M3 - Article

C2 - 6638217

AN - SCOPUS:0020858791

VL - 245

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 5 Pt 1

ER -