Cerebral Hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits

Wayne Clark, Ken P. Madden, Patrick D. Lyden, Justin A. Zivin

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We studied the incidence of cerebral hemorrhage in an animal model of embolic stroke to determine the safety of aspirin, heparin, and tissue plasminogen activator therapies. We occluded the middle cerebral arteries of rabbits with labeled blood clots and administered either tissue plasminogen activator, heparin, aspirin, tissue plasminogen activator plus aspirin, tissue plasminogen activator plus heparin, or saline at various times after stroke. Compared to saline controls, both the aspirin-only and the tissue plasminogen activator-plus-aspirin groups had a significantly higher incidence of cerebral hemorrhage, whereas the heparin and tissue plasminogen activator combination groups did not. We conclude that aspirin antiplatelet therapy alone may increase the risk of hemorrhagic infarction, whereas heparin or tissue plasminogen activator therapy appears to be relatively safe.

Original languageEnglish (US)
Pages (from-to)872-876
Number of pages5
JournalStroke
Volume22
Issue number7
StatePublished - 1991

Fingerprint

Thrombolytic Therapy
Tissue Plasminogen Activator
Aspirin
Heparin
Rabbits
Cerebral Hemorrhage
Therapeutics
Stroke
Incidence
Middle Cerebral Artery
Infarction
Thrombosis
Animal Models
Safety

Keywords

  • Aspirin
  • Cerebral hemorrhage
  • Rabbits
  • Thrombolytic therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Clark, W., Madden, K. P., Lyden, P. D., & Zivin, J. A. (1991). Cerebral Hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits. Stroke, 22(7), 872-876.

Cerebral Hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits. / Clark, Wayne; Madden, Ken P.; Lyden, Patrick D.; Zivin, Justin A.

In: Stroke, Vol. 22, No. 7, 1991, p. 872-876.

Research output: Contribution to journalArticle

Clark, W, Madden, KP, Lyden, PD & Zivin, JA 1991, 'Cerebral Hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits', Stroke, vol. 22, no. 7, pp. 872-876.
Clark, Wayne ; Madden, Ken P. ; Lyden, Patrick D. ; Zivin, Justin A. / Cerebral Hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits. In: Stroke. 1991 ; Vol. 22, No. 7. pp. 872-876.
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