Cerebral effects of sevoflurane in the dog: Comparison with isoflurane and enflurane

M. S. Scheller, K. Nakakimura, J. E. Fleischer, Mark Zornow

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The cerebral effects of sevoflurane were compared in dogs with those of enflurane and isoflurane. Initially, the minimum alveolar concentrations (MAC) of sevoflurane and enflurane were determined and the electroencephalo-graphic (EEG) responses to increasing doses of sevoflurane (1.5, 2.0 and 2.5 MAC) or enflurane (1.5 and 2.0 MAC) in unparalysed animals were examined. Administration of sevoflurane was not associated with seizure activity at any concentration either during normocapnia (PaCO2 5.3 kPa) or hypocapnia (PaCO2 2.7 kPa), even in the presence of intense auditory stimuli. All dogs anaesthetized with enflurane demonstrated sustained EEG and motor evidence of seizure activity induced by auditory stimuli at concentrations of enflurane > 1 MAC, particularly during hypocapnia. In a separate group of dogs, the effects of increasing concentrations of sevoflurane and isoflurane (0.5, 1.5 and 2.15 MAC) were compared directly on arterial pressure, cardiac output and heart rate, cerebral blood flow and the cerebral metabolic rate for oxygen (CMRO2) using the venous outflow technique. Sevoflurane, in common with isoflurane, had minimal effects on cerebral blood flow at the concentrations studied, but significantly reduced the CMRO2 at end-tidal concentrations sufficient to produce a burst suppression pattern on the EEG (approximately 2.15 MAC). Both sevoflurane and isoflurane significantly decreased arterial pressure in a dose-dependent manner, but neither drug significantly altered cardiac output.

Original languageEnglish (US)
Pages (from-to)388-392
Number of pages5
JournalBritish Journal of Anaesthesia
Volume65
Issue number3
DOIs
StatePublished - Sep 1990
Externally publishedYes

Fingerprint

Isoflurane
Enflurane
isoflurane
Blood
Dogs
dogs
cardiac output
seizures
Cerebrovascular Circulation
blood flow
Animals
Hypocapnia
Oxygen
Cardiac Output
dosage
Arterial Pressure
Seizures
heart rate
Blood Flow
oxygen

Keywords

  • Anaesthetics, volatile: sevoflurane
  • Arterial pressure: drug effects
  • Brain: blood flow, electro-encephalography, oxygen consumption
  • Heart: cardiac output, heart rate

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Cerebral effects of sevoflurane in the dog : Comparison with isoflurane and enflurane. / Scheller, M. S.; Nakakimura, K.; Fleischer, J. E.; Zornow, Mark.

In: British Journal of Anaesthesia, Vol. 65, No. 3, 09.1990, p. 388-392.

Research output: Contribution to journalArticle

Scheller, M. S. ; Nakakimura, K. ; Fleischer, J. E. ; Zornow, Mark. / Cerebral effects of sevoflurane in the dog : Comparison with isoflurane and enflurane. In: British Journal of Anaesthesia. 1990 ; Vol. 65, No. 3. pp. 388-392.
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