Cerebral carbohydrate metabolism during severe ischemia in fetal sheep

C. R. Chao, Alan (Roger) Hohimer, J. M. Bissonnette

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of cephalic hypotension on brain metabolism was studied in 10 unanesthetized, normoxic (P(a)O2 > 17 mm Hg), late-gestation fetal lambs. Perfusion pressure (cephalic arterial minus sagittal venous pressure) was 40 ± 1 mm Hg (SEM) during control and was reduced to 10 ± 1 by occlusion of the Grachio-cephalic artery. Cerebral blood flow was measured with microspheres, and arterial and sagittal vein blood samples were analyzed for oxygen content, glucose, and lactate. During the occlusion, oxygen consumption decreased from 125 ± 8 to 95 ± 4 (p <0.05) (all values μmol 100 g-1 min-1), and glucose uptake increased from 20 ± 3 to 25 ± 1 (p <0.05). During the control period, there was no net lactate flux; during the occlusion, lactate excretion was 5.7 ± 1.4 (p <0.005). The control glucose and oxygen uptakes demonstrated a normal 6:1 molar ratio; however, during the occlusion, 9.4 μmol 100 g-1 glucose min-1 were taken up in excess of expected aerobic glucose metabolism. If all of this glucose were anaerobically metabolized to lactate, three times the measured efflux would be produced. The transport properties of the fetal blood-brain barrier may be important factors in perinatal brain injury.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume9
Issue number1
StatePublished - 1989

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Carbohydrate Metabolism
Sheep
Ischemia
Glucose
Lactic Acid
Head
Cerebrovascular Circulation
Oxygen
Venous Pressure
Blood-Brain Barrier
Fetal Blood
Microspheres
Oxygen Consumption
Hypotension
Brain Injuries
Veins
Arterial Pressure
Arteries
Perfusion
Pregnancy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

Cerebral carbohydrate metabolism during severe ischemia in fetal sheep. / Chao, C. R.; Hohimer, Alan (Roger); Bissonnette, J. M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 9, No. 1, 1989, p. 53-57.

Research output: Contribution to journalArticle

Chao, CR, Hohimer, AR & Bissonnette, JM 1989, 'Cerebral carbohydrate metabolism during severe ischemia in fetal sheep', Journal of Cerebral Blood Flow and Metabolism, vol. 9, no. 1, pp. 53-57.
Chao, C. R. ; Hohimer, Alan (Roger) ; Bissonnette, J. M. / Cerebral carbohydrate metabolism during severe ischemia in fetal sheep. In: Journal of Cerebral Blood Flow and Metabolism. 1989 ; Vol. 9, No. 1. pp. 53-57.
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