Cerebral blood volume measurements by T2*-weighted MRI and contrast infusion

George C. Newman, E. Delucia-Deranja, A. Tudorica, F. E. Hospod, C. S. Patlak

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A reliable, accurate, and accessible method for measuring cerebral blood volume (CBV) has been developed based on T2*-weighted MRI and a 1-min infusion of gadolinium instead of a bolus. Computer simulations predict that this infusion CBV method will have a signal-to-noise ratio (SNR) 3-5 times greater than that obtained by area-under-the-curve (AUC) methods, with high accuracy over a wide range of arterial, tissue, and MRI conditions. In six healthy controls, the CBV was 1.87 ± 0.44 in white matter (WM), 3.40 ± 0.44 in deep gray matter (DGM), and 3.84 ± 1.87 mi blood/100 g tissue in cortical GM (CGM). The mean GM/WM ratio was 1.94. In five patients with bilateral carotid disease, the corresponding values were 2.63 ± 0.33, 4.72 ± 0.33, and 5.27 ± 2.40 mi blood/100 g tissue, all of which were significantly different from controls. AUC values were generally higher and failed to demonstrate differences between controls and patients. The infusion method shows great potential for providing reliable, accurate, and accessible CBV values with the ability to discriminate physiologic or pathological volume changes under a wide range of conditions.

Original languageEnglish (US)
Pages (from-to)844-855
Number of pages12
JournalMagnetic Resonance in Medicine
Volume50
Issue number4
DOIs
StatePublished - Oct 1 2003

Keywords

  • Brain
  • Carotid artery disease
  • Cerebral blood volume (CBV)
  • Cerebral perfusion
  • Human
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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