Cerebellar rTMS for motor control in progressive supranuclear palsy

M. L. Dale, W. H. DeVries, M. Mancini, M. S. George

Research output: Contribution to journalLetter

Abstract

Background: Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders. Objective/hypothesis: Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP). Methods: We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment. Results: After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable. Conclusion: Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.

Original languageEnglish (US)
Pages (from-to)1588-1591
Number of pages4
JournalBrain Stimulation
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2019

Fingerprint

Progressive Supranuclear Palsy
Brain
Neuronavigation
Neurodegenerative Diseases
Therapeutics
Inhibition (Psychology)

Keywords

  • Balance
  • Cerebellum
  • Posturography
  • Progressive supranuclear palsy
  • Speech
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Dale, M. L., DeVries, W. H., Mancini, M., & George, M. S. (2019). Cerebellar rTMS for motor control in progressive supranuclear palsy. Brain Stimulation, 12(6), 1588-1591. https://doi.org/10.1016/j.brs.2019.07.017

Cerebellar rTMS for motor control in progressive supranuclear palsy. / Dale, M. L.; DeVries, W. H.; Mancini, M.; George, M. S.

In: Brain Stimulation, Vol. 12, No. 6, 01.11.2019, p. 1588-1591.

Research output: Contribution to journalLetter

Dale, ML, DeVries, WH, Mancini, M & George, MS 2019, 'Cerebellar rTMS for motor control in progressive supranuclear palsy', Brain Stimulation, vol. 12, no. 6, pp. 1588-1591. https://doi.org/10.1016/j.brs.2019.07.017
Dale, M. L. ; DeVries, W. H. ; Mancini, M. ; George, M. S. / Cerebellar rTMS for motor control in progressive supranuclear palsy. In: Brain Stimulation. 2019 ; Vol. 12, No. 6. pp. 1588-1591.
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