Cerebellar rTMS for motor control in progressive supranuclear palsy

M. L. Dale, W. H. DeVries, M. Mancini, M. S. George

Research output: Contribution to journalLetter

1 Scopus citations

Abstract

Background: Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders. Objective/hypothesis: Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP). Methods: We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment. Results: After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable. Conclusion: Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.

Original languageEnglish (US)
Pages (from-to)1588-1591
Number of pages4
JournalBrain Stimulation
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2019

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Keywords

  • Balance
  • Cerebellum
  • Posturography
  • Progressive supranuclear palsy
  • Speech
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Dale, M. L., DeVries, W. H., Mancini, M., & George, M. S. (2019). Cerebellar rTMS for motor control in progressive supranuclear palsy. Brain Stimulation, 12(6), 1588-1591. https://doi.org/10.1016/j.brs.2019.07.017