TY - JOUR
T1 - Cerebellar Dysfunction in Hand-Schuller-Christian Disease
AU - Braunstein, Glenn D.
AU - Whitaker, John N.
AU - Kohler, Peter O.
PY - 1973/9
Y1 - 1973/9
N2 - Diabetes insipidus and growth retardation are common manifestations of hypothalamic involvement in patients with Hand-Schuller-Christian disease (HSCD). Involvement of other areas of the central nervous system (CNS) has been reported infrequently. We have studied 13 patients with HSCD. Four of these patients exhibited signs of extrahypothalamic CNS disease, manifested primarily by impairment of cerebellar function. One patient showed bilateral dentate nuclear calcification, a radiologic sign not previously reported in this disease. Although histologic examination was not possible, the nature of the clinical and radiologic signs suggest that intracerebellar involvement in patients with HSCD is more common than previously appreciated.
AB - Diabetes insipidus and growth retardation are common manifestations of hypothalamic involvement in patients with Hand-Schuller-Christian disease (HSCD). Involvement of other areas of the central nervous system (CNS) has been reported infrequently. We have studied 13 patients with HSCD. Four of these patients exhibited signs of extrahypothalamic CNS disease, manifested primarily by impairment of cerebellar function. One patient showed bilateral dentate nuclear calcification, a radiologic sign not previously reported in this disease. Although histologic examination was not possible, the nature of the clinical and radiologic signs suggest that intracerebellar involvement in patients with HSCD is more common than previously appreciated.
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U2 - 10.1001/archinte.1973.03650090067012
DO - 10.1001/archinte.1973.03650090067012
M3 - Article
C2 - 4783019
AN - SCOPUS:0015664782
SN - 0003-9926
VL - 132
SP - 387
EP - 390
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 3
ER -