Central shunt flows and pressures in the mature fetal lamb

Debra Anderson, J. M. Bissonnette, J. J. Faber, Kent Thornburg

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    Two to eight days after surgery, we determined biventricular cardiac output with the microsphere-dilution method and individual ventricular output with an electromagnetic flow sensor in 12 fetal lambs. Mean biventricular output was 462ml·min-1·kg:-1. Right ventricular output was 60%, pulmonary blood flow was 6%, blood flow in the ductus arteriosus was 54%, flow through the foramen ovale was 34%, and flow in the descending thoracic aorta above the ductus arteriosus was 12% of the biventricular cardiac output. Foramen ovale flow did not correlate with the pressure difference between the atria. The flow through the foramen ovale correlated positively with the flow in the inferior caval vein. It was concluded the shunt flow through the foramen ovale is mainly determined by the kinetic energy of the blood in the 'lower atrial inflow tract'. Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood. This was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.

    Original languageEnglish (US)
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume10
    Issue number1
    StatePublished - 1981

    Fingerprint

    Foramen Ovale
    Ductus Arteriosus
    Pressure
    Thoracic Aorta
    Cardiac Output
    Venae Cavae
    Electromagnetic Phenomena
    Ambulatory Surgical Procedures
    Fetal Blood
    Microspheres
    Veins
    Homeostasis
    Oxygen
    Lung

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Central shunt flows and pressures in the mature fetal lamb. / Anderson, Debra; Bissonnette, J. M.; Faber, J. J.; Thornburg, Kent.

    In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 10, No. 1, 1981.

    Research output: Contribution to journalArticle

    @article{a0c5cdb7f0f74d938dba9ece838b8f30,
    title = "Central shunt flows and pressures in the mature fetal lamb",
    abstract = "Two to eight days after surgery, we determined biventricular cardiac output with the microsphere-dilution method and individual ventricular output with an electromagnetic flow sensor in 12 fetal lambs. Mean biventricular output was 462ml·min-1·kg:-1. Right ventricular output was 60{\%}, pulmonary blood flow was 6{\%}, blood flow in the ductus arteriosus was 54{\%}, flow through the foramen ovale was 34{\%}, and flow in the descending thoracic aorta above the ductus arteriosus was 12{\%} of the biventricular cardiac output. Foramen ovale flow did not correlate with the pressure difference between the atria. The flow through the foramen ovale correlated positively with the flow in the inferior caval vein. It was concluded the shunt flow through the foramen ovale is mainly determined by the kinetic energy of the blood in the 'lower atrial inflow tract'. Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood. This was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.",
    author = "Debra Anderson and Bissonnette, {J. M.} and Faber, {J. J.} and Kent Thornburg",
    year = "1981",
    language = "English (US)",
    volume = "10",
    journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
    issn = "1931-857X",
    publisher = "American Physiological Society",
    number = "1",

    }

    TY - JOUR

    T1 - Central shunt flows and pressures in the mature fetal lamb

    AU - Anderson, Debra

    AU - Bissonnette, J. M.

    AU - Faber, J. J.

    AU - Thornburg, Kent

    PY - 1981

    Y1 - 1981

    N2 - Two to eight days after surgery, we determined biventricular cardiac output with the microsphere-dilution method and individual ventricular output with an electromagnetic flow sensor in 12 fetal lambs. Mean biventricular output was 462ml·min-1·kg:-1. Right ventricular output was 60%, pulmonary blood flow was 6%, blood flow in the ductus arteriosus was 54%, flow through the foramen ovale was 34%, and flow in the descending thoracic aorta above the ductus arteriosus was 12% of the biventricular cardiac output. Foramen ovale flow did not correlate with the pressure difference between the atria. The flow through the foramen ovale correlated positively with the flow in the inferior caval vein. It was concluded the shunt flow through the foramen ovale is mainly determined by the kinetic energy of the blood in the 'lower atrial inflow tract'. Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood. This was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.

    AB - Two to eight days after surgery, we determined biventricular cardiac output with the microsphere-dilution method and individual ventricular output with an electromagnetic flow sensor in 12 fetal lambs. Mean biventricular output was 462ml·min-1·kg:-1. Right ventricular output was 60%, pulmonary blood flow was 6%, blood flow in the ductus arteriosus was 54%, flow through the foramen ovale was 34%, and flow in the descending thoracic aorta above the ductus arteriosus was 12% of the biventricular cardiac output. Foramen ovale flow did not correlate with the pressure difference between the atria. The flow through the foramen ovale correlated positively with the flow in the inferior caval vein. It was concluded the shunt flow through the foramen ovale is mainly determined by the kinetic energy of the blood in the 'lower atrial inflow tract'. Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood. This was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.

    UR - http://www.scopus.com/inward/record.url?scp=0019521206&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0019521206&partnerID=8YFLogxK

    M3 - Article

    VL - 10

    JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

    JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

    SN - 1931-857X

    IS - 1

    ER -