Central Sensitivity Syndromes

Mounting Pathophysiologic Evidence to Link Fibromyalgia with Other Common Chronic Pain Disorders

Lindsay L. Kindler, Robert (Rob) Bennett, Kim Jones

    Research output: Contribution to journalArticle

    82 Citations (Scopus)

    Abstract

    The aim of this study was to review emerging data from the fields of nursing, rheumatology, dentistry, gastroenterology, gynecology, neurology, and orthopedics that support or dispute pathophysiologic similarities in pain syndromes studied by each specialty. A literature search was performed through PubMed and Ovid using the terms fibromyalgia, temporomandibular joint disorder, irritable bowel syndrome, irritable bladder/interstitial cystitis, headache, chronic low back pain, chronic neck pain, functional syndromes, and somatization. Each term was linked with pathophysiology and/or central sensitization. This paper presents a review of relevant articles with a specific goal of identifying pathophysiologic findings related to nociceptive processing. The extant literature presents considerable overlap in the pathophysiology of these diagnoses. Given the psychosomatic lens through which many of these disorders are viewed, demonstration of evidence-based links supporting shared pathophysiology between these disorders could provide direction to clinicians and researchers working to treat these diagnoses. "Central sensitivity syndromes" denotes an emerging nomenclature that could be embraced by researchers investigating each of these disorders. Moreover, a shared paradigm would be useful in promoting cross-fertilization between researchers. Scientists and clinicians could most effectively forward the understanding and treatment of fibromyalgia and other common chronic pain disorders through an appreciation of their shared pathophysiology.

    Original languageEnglish (US)
    Pages (from-to)15-24
    Number of pages10
    JournalPain Management Nursing
    Volume12
    Issue number1
    DOIs
    StatePublished - Mar 2011

    Fingerprint

    Somatoform Disorders
    Fibromyalgia
    Chronic Pain
    Research Personnel
    Central Nervous System Sensitization
    Interstitial Cystitis
    Temporomandibular Joint Disorders
    Dissent and Disputes
    Neck Pain
    Irritable Bowel Syndrome
    Rheumatology
    Gastroenterology
    Neurology
    Low Back Pain
    Dentistry
    Gynecology
    Fertilization
    PubMed
    Terminology
    Lenses

    ASJC Scopus subject areas

    • Advanced and Specialized Nursing

    Cite this

    Central Sensitivity Syndromes : Mounting Pathophysiologic Evidence to Link Fibromyalgia with Other Common Chronic Pain Disorders. / Kindler, Lindsay L.; Bennett, Robert (Rob); Jones, Kim.

    In: Pain Management Nursing, Vol. 12, No. 1, 03.2011, p. 15-24.

    Research output: Contribution to journalArticle

    Kindler, Lindsay L. ; Bennett, Robert (Rob) ; Jones, Kim. / Central Sensitivity Syndromes : Mounting Pathophysiologic Evidence to Link Fibromyalgia with Other Common Chronic Pain Disorders. In: Pain Management Nursing. 2011 ; Vol. 12, No. 1. pp. 15-24.
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