Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation

S. D. Munger, A. P. Lane, Haining Zhong, T. Leinders-Zufall, K. W. Yau, F. Zufall, R. R. Reed

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Heteromultimeric cyclic nucleotide-gated (CNG) channels play a central role in the transduction of odorant signals and subsequent adaptation. The contributions of individual subunits to native channel function in olfactory receptor neurons remain unclear. Here, we show that the targeted deletion of the mouse CNGA4 gene, which encodes a modulatory CNG subunit, results in a defect in odorant-dependent adaptation. Channels in excised membrane patches from the CNGA4 null mouse exhibited slower Ca2+-calmodulin-mediated channel desensitization. Thus, the CNGA4 subunit accelerates the Ca2+-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system.

Original languageEnglish (US)
Pages (from-to)2172-2175
Number of pages4
JournalScience
Volume294
Issue number5549
DOIs
StatePublished - Dec 7 2001
Externally publishedYes

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Calmodulin
Cyclic Nucleotide-Gated Cation Channels
Olfactory Receptor Neurons
Cyclic Nucleotides
Signal Transduction
Membranes
Genes
Odorants

ASJC Scopus subject areas

  • General

Cite this

Munger, S. D., Lane, A. P., Zhong, H., Leinders-Zufall, T., Yau, K. W., Zufall, F., & Reed, R. R. (2001). Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science, 294(5549), 2172-2175. https://doi.org/10.1126/science.1063224

Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. / Munger, S. D.; Lane, A. P.; Zhong, Haining; Leinders-Zufall, T.; Yau, K. W.; Zufall, F.; Reed, R. R.

In: Science, Vol. 294, No. 5549, 07.12.2001, p. 2172-2175.

Research output: Contribution to journalArticle

Munger, SD, Lane, AP, Zhong, H, Leinders-Zufall, T, Yau, KW, Zufall, F & Reed, RR 2001, 'Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation', Science, vol. 294, no. 5549, pp. 2172-2175. https://doi.org/10.1126/science.1063224
Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F et al. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-2175. https://doi.org/10.1126/science.1063224
Munger, S. D. ; Lane, A. P. ; Zhong, Haining ; Leinders-Zufall, T. ; Yau, K. W. ; Zufall, F. ; Reed, R. R. / Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. In: Science. 2001 ; Vol. 294, No. 5549. pp. 2172-2175.
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