Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers

Brian Wong, J. W M Gold, A. E. Brown, M. Lange, R. Fried, M. Grieco, D. Mildvan, J. Giron, M. L. Tapper, C. W. Lerner

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Central-nervous-system toxoplasmosis developed in 7 of 269 patients with acquired immunodeficiency syndrome reported to the New York City Health Department through July 1982. Focal neurologic abnormalities, mass lesions on computed-tomographic brain scans, lymphocytic cerebrospinal fluid pleocytosis, and detectable IgG antibody to Toxoplasma gondii were common; but IgG titers of 1:1024 or more, IgM antibody to T. gondii, and positive open brain biopsies were uncommon. Serologic findings suggested that the disease resulted from recrudescent rather than primary infection. Four of the five patients improved when treated with sulfonamides and pyrimethamine, but 2 had relapses. An aggressive diagnostic approach and sometimes even empiric therapy are warranted when central-nervous-system toxoplasmosis is suspected in a seropositive patients with the acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalAnnals of Internal Medicine
Volume100
Issue number1
StatePublished - 1984
Externally publishedYes

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Cerebral Toxoplasmosis
Drug Users
Toxoplasma
Acquired Immunodeficiency Syndrome
Immunoglobulin G
Nervous System Malformations
Pyrimethamine
Antibodies
Leukocytosis
Sulfonamides
Brain
Immunoglobulin M
Cerebrospinal Fluid
Biopsy
Recurrence
Health
Infection
Sexual Minorities
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wong, B., Gold, J. W. M., Brown, A. E., Lange, M., Fried, R., Grieco, M., ... Lerner, C. W. (1984). Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers. Annals of Internal Medicine, 100(1), 36-42.

Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers. / Wong, Brian; Gold, J. W M; Brown, A. E.; Lange, M.; Fried, R.; Grieco, M.; Mildvan, D.; Giron, J.; Tapper, M. L.; Lerner, C. W.

In: Annals of Internal Medicine, Vol. 100, No. 1, 1984, p. 36-42.

Research output: Contribution to journalArticle

Wong, B, Gold, JWM, Brown, AE, Lange, M, Fried, R, Grieco, M, Mildvan, D, Giron, J, Tapper, ML & Lerner, CW 1984, 'Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers', Annals of Internal Medicine, vol. 100, no. 1, pp. 36-42.
Wong B, Gold JWM, Brown AE, Lange M, Fried R, Grieco M et al. Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers. Annals of Internal Medicine. 1984;100(1):36-42.
Wong, Brian ; Gold, J. W M ; Brown, A. E. ; Lange, M. ; Fried, R. ; Grieco, M. ; Mildvan, D. ; Giron, J. ; Tapper, M. L. ; Lerner, C. W. / Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers. In: Annals of Internal Medicine. 1984 ; Vol. 100, No. 1. pp. 36-42.
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