Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers

B. Wong, J. W.M. Gold, A. E. Brown, M. Lange, R. Fried, M. Grieco, D. Mildvan, J. Giron, M. L. Tapper, C. W. Lerner

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

Central-nervous-system toxoplasmosis developed in 7 of 269 patients with acquired immunodeficiency syndrome reported to the New York City Health Department through July 1982. Focal neurologic abnormalities, mass lesions on computed-tomographic brain scans, lymphocytic cerebrospinal fluid pleocytosis, and detectable IgG antibody to Toxoplasma gondii were common; but IgG titers of 1:1024 or more, IgM antibody to T. gondii, and positive open brain biopsies were uncommon. Serologic findings suggested that the disease resulted from recrudescent rather than primary infection. Four of the five patients improved when treated with sulfonamides and pyrimethamine, but 2 had relapses. An aggressive diagnostic approach and sometimes even empiric therapy are warranted when central-nervous-system toxoplasmosis is suspected in a seropositive patients with the acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalAnnals of internal medicine
Volume100
Issue number1
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Internal Medicine

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    Wong, B., Gold, J. W. M., Brown, A. E., Lange, M., Fried, R., Grieco, M., Mildvan, D., Giron, J., Tapper, M. L., & Lerner, C. W. (1984). Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers. Annals of internal medicine, 100(1), 36-42. https://doi.org/10.7326/0003-4819-100-1-36