Central melanocortin receptors mediate changes in food intake in the rhesus macaque

Frank H. Koegler, Kevin Grove, Andrew Schiffmacher, M (Susan) Smith, Judy L. Cameron

    Research output: Contribution to journalArticle

    53 Citations (Scopus)

    Abstract

    In rodents, stimulation of melanocortin-3 and -4 receptor subtypes (MC3-R and MC4-R) causes a reduction in food intake, whereas antagonism of MC3-R and MC4-R increases food intake. This report describes the effects of the stable αMSH analog, NDP-MSH ([Nle4, D-Phe7]αMSH), and the endogenous αMSH receptor antagonist, agouti-related protein, on feeding behavior in adult male rhesus macaques. Infusion of NDP-MSH into the lateral cerebral ventricle dose dependently suppressed intake of a normally scheduled meal without affecting nonfeeding behaviors. Conversely, infusion of agouti-related protein stimulated food intake during the scheduled afternoon meal. In addition to these physiological experiments, the effect of fasting on hypothalamic POMC gene expression was assessed by in situ hybridization. Missing a single meal or fasting for 48 h caused a similar reduction in POMC gene expression in the arcuate nucleus. These results demonstrate that in the primate, central melanocortin receptors can acutely regulate food intake and suggest that the central melanocortinergic system is a physiological regulator of energy balance in primate species.

    Original languageEnglish (US)
    Pages (from-to)2586-2592
    Number of pages7
    JournalEndocrinology
    Volume142
    Issue number6
    DOIs
    StatePublished - 2001

    Fingerprint

    Melanocortin Receptors
    Macaca mulatta
    Melanocyte-Stimulating Hormones
    Agouti-Related Protein
    Eating
    Meals
    Pro-Opiomelanocortin
    Primates
    Fasting
    Receptor, Melanocortin, Type 3
    Receptor, Melanocortin, Type 4
    Gene Expression
    Cerebral Ventricles
    Arcuate Nucleus of Hypothalamus
    Lateral Ventricles
    Feeding Behavior
    In Situ Hybridization
    Rodentia

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Koegler, F. H., Grove, K., Schiffmacher, A., Smith, M. S., & Cameron, J. L. (2001). Central melanocortin receptors mediate changes in food intake in the rhesus macaque. Endocrinology, 142(6), 2586-2592. https://doi.org/10.1210/en.142.6.2586

    Central melanocortin receptors mediate changes in food intake in the rhesus macaque. / Koegler, Frank H.; Grove, Kevin; Schiffmacher, Andrew; Smith, M (Susan); Cameron, Judy L.

    In: Endocrinology, Vol. 142, No. 6, 2001, p. 2586-2592.

    Research output: Contribution to journalArticle

    Koegler, FH, Grove, K, Schiffmacher, A, Smith, MS & Cameron, JL 2001, 'Central melanocortin receptors mediate changes in food intake in the rhesus macaque', Endocrinology, vol. 142, no. 6, pp. 2586-2592. https://doi.org/10.1210/en.142.6.2586
    Koegler, Frank H. ; Grove, Kevin ; Schiffmacher, Andrew ; Smith, M (Susan) ; Cameron, Judy L. / Central melanocortin receptors mediate changes in food intake in the rhesus macaque. In: Endocrinology. 2001 ; Vol. 142, No. 6. pp. 2586-2592.
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