Central mechanisms of pain suppression: Central mechanisms of pain modulation

Richard Bodnar, Mary Heinricher

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In contrast to a classic view that the brain was a passive receiver of the pain message, Melzack and Wall proposed in 1965 that the brain exerted descending control upon spinal nociceptive transmission. This chapter reviews the substrates mediating endogenous pain-modulation. The respective roles of the ventrolateral periaqueductal gray (vlPAG) and rostroventromedial medualla (RVM) in the mediation of not only pain-inhibitory, but also pain-facilitatory responses are described behaviorally, neuroanatomically, neurochemically and neurophysiologically. How this intrinsic pain-modulatory system is activated by other brain nuclei (limbic system and cortex) and by exogeneous environmental factors is described. The emergence of sex differences and neurohormonal factors in mediating pain modulation is also considered. The neurophysiological underpinnings of RVM “ON-" and “OFF-cells” and their respective roles in endogenous pain-facilitatory and pain-inhibitory responses are discussed in detail. Finally, how these pain-modulatory responses relate to other neurobehavioral adapatations are considered, including how animal studies can inform human pain conditions and their detection through functional imaging.

Original languageEnglish (US)
Title of host publicationNeuroscience in the 21st Century
Subtitle of host publicationFrom Basic to Clinical, Second Edition
PublisherSpringer New York
Pages3439-3464
Number of pages26
ISBN (Electronic)9781493934744
ISBN (Print)9781493934737
DOIs
StatePublished - Jan 1 2016

Fingerprint

pain
Pain
brain
Brain
Limbic System
Periaqueductal Gray
gender differences
Sex Characteristics
cortex
image analysis
environmental factors

Keywords

  • Allodynia
  • Analgesia
  • Anti-hyperalgesia
  • Antinociception
  • Diffuse noxious inhibitory controls (DNIC)
  • Hyperalgesia
  • Hypoalgesia
  • Intrinsic pain-modulatory system
  • Intrinsic painmodulatory system. see also PAG-RVM system
  • Opioid tolerance
  • PAG
  • PAG-RVM system
  • Pronociception
  • Ventrolateral periaqueductal gray (vlPAG)

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

Cite this

Bodnar, R., & Heinricher, M. (2016). Central mechanisms of pain suppression: Central mechanisms of pain modulation. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition (pp. 3439-3464). Springer New York. https://doi.org/10.1007/978-1-4939-3474-4_102

Central mechanisms of pain suppression : Central mechanisms of pain modulation. / Bodnar, Richard; Heinricher, Mary.

Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. p. 3439-3464.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bodnar, R & Heinricher, M 2016, Central mechanisms of pain suppression: Central mechanisms of pain modulation. in Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, pp. 3439-3464. https://doi.org/10.1007/978-1-4939-3474-4_102
Bodnar R, Heinricher M. Central mechanisms of pain suppression: Central mechanisms of pain modulation. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York. 2016. p. 3439-3464 https://doi.org/10.1007/978-1-4939-3474-4_102
Bodnar, Richard ; Heinricher, Mary. / Central mechanisms of pain suppression : Central mechanisms of pain modulation. Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. pp. 3439-3464
@inbook{a8e658b031f64c3fab20bfb6e16d61e7,
title = "Central mechanisms of pain suppression: Central mechanisms of pain modulation",
abstract = "In contrast to a classic view that the brain was a passive receiver of the pain message, Melzack and Wall proposed in 1965 that the brain exerted descending control upon spinal nociceptive transmission. This chapter reviews the substrates mediating endogenous pain-modulation. The respective roles of the ventrolateral periaqueductal gray (vlPAG) and rostroventromedial medualla (RVM) in the mediation of not only pain-inhibitory, but also pain-facilitatory responses are described behaviorally, neuroanatomically, neurochemically and neurophysiologically. How this intrinsic pain-modulatory system is activated by other brain nuclei (limbic system and cortex) and by exogeneous environmental factors is described. The emergence of sex differences and neurohormonal factors in mediating pain modulation is also considered. The neurophysiological underpinnings of RVM “ON-{"} and “OFF-cells” and their respective roles in endogenous pain-facilitatory and pain-inhibitory responses are discussed in detail. Finally, how these pain-modulatory responses relate to other neurobehavioral adapatations are considered, including how animal studies can inform human pain conditions and their detection through functional imaging.",
keywords = "Allodynia, Analgesia, Anti-hyperalgesia, Antinociception, Diffuse noxious inhibitory controls (DNIC), Hyperalgesia, Hypoalgesia, Intrinsic pain-modulatory system, Intrinsic painmodulatory system. see also PAG-RVM system, Opioid tolerance, PAG, PAG-RVM system, Pronociception, Ventrolateral periaqueductal gray (vlPAG)",
author = "Richard Bodnar and Mary Heinricher",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-3474-4_102",
language = "English (US)",
isbn = "9781493934737",
pages = "3439--3464",
booktitle = "Neuroscience in the 21st Century",
publisher = "Springer New York",

}

TY - CHAP

T1 - Central mechanisms of pain suppression

T2 - Central mechanisms of pain modulation

AU - Bodnar, Richard

AU - Heinricher, Mary

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In contrast to a classic view that the brain was a passive receiver of the pain message, Melzack and Wall proposed in 1965 that the brain exerted descending control upon spinal nociceptive transmission. This chapter reviews the substrates mediating endogenous pain-modulation. The respective roles of the ventrolateral periaqueductal gray (vlPAG) and rostroventromedial medualla (RVM) in the mediation of not only pain-inhibitory, but also pain-facilitatory responses are described behaviorally, neuroanatomically, neurochemically and neurophysiologically. How this intrinsic pain-modulatory system is activated by other brain nuclei (limbic system and cortex) and by exogeneous environmental factors is described. The emergence of sex differences and neurohormonal factors in mediating pain modulation is also considered. The neurophysiological underpinnings of RVM “ON-" and “OFF-cells” and their respective roles in endogenous pain-facilitatory and pain-inhibitory responses are discussed in detail. Finally, how these pain-modulatory responses relate to other neurobehavioral adapatations are considered, including how animal studies can inform human pain conditions and their detection through functional imaging.

AB - In contrast to a classic view that the brain was a passive receiver of the pain message, Melzack and Wall proposed in 1965 that the brain exerted descending control upon spinal nociceptive transmission. This chapter reviews the substrates mediating endogenous pain-modulation. The respective roles of the ventrolateral periaqueductal gray (vlPAG) and rostroventromedial medualla (RVM) in the mediation of not only pain-inhibitory, but also pain-facilitatory responses are described behaviorally, neuroanatomically, neurochemically and neurophysiologically. How this intrinsic pain-modulatory system is activated by other brain nuclei (limbic system and cortex) and by exogeneous environmental factors is described. The emergence of sex differences and neurohormonal factors in mediating pain modulation is also considered. The neurophysiological underpinnings of RVM “ON-" and “OFF-cells” and their respective roles in endogenous pain-facilitatory and pain-inhibitory responses are discussed in detail. Finally, how these pain-modulatory responses relate to other neurobehavioral adapatations are considered, including how animal studies can inform human pain conditions and their detection through functional imaging.

KW - Allodynia

KW - Analgesia

KW - Anti-hyperalgesia

KW - Antinociception

KW - Diffuse noxious inhibitory controls (DNIC)

KW - Hyperalgesia

KW - Hypoalgesia

KW - Intrinsic pain-modulatory system

KW - Intrinsic painmodulatory system. see also PAG-RVM system

KW - Opioid tolerance

KW - PAG

KW - PAG-RVM system

KW - Pronociception

KW - Ventrolateral periaqueductal gray (vlPAG)

UR - http://www.scopus.com/inward/record.url?scp=85018883284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018883284&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-3474-4_102

DO - 10.1007/978-1-4939-3474-4_102

M3 - Chapter

AN - SCOPUS:85018883284

SN - 9781493934737

SP - 3439

EP - 3464

BT - Neuroscience in the 21st Century

PB - Springer New York

ER -