Central hypothyroidism

Mary Samuels, E. C. Ridgway

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary lesions. The diagnosis rests on documentation of clinical and biochemical hypothyroidism with an inappropriately low or nonelevated serum TSH level. Recent studies suggest that the temporal pattern of TSH secretion, as well as TSH structure, is altered in central hypothyroidism, providing a mechanism for the induction of the hypothyroid state in this condition.

Original languageEnglish (US)
Pages (from-to)903-919
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Volume21
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Pituitary Hormones
Hypothyroidism
Neurologic Manifestations
Documentation
Thyroid Gland
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Central hypothyroidism. / Samuels, Mary; Ridgway, E. C.

In: Endocrinology and Metabolism Clinics of North America, Vol. 21, No. 4, 1992, p. 903-919.

Research output: Contribution to journalArticle

Samuels, Mary ; Ridgway, E. C. / Central hypothyroidism. In: Endocrinology and Metabolism Clinics of North America. 1992 ; Vol. 21, No. 4. pp. 903-919.
@article{8d1d7cb6cbcf470fa73812a2a3bf8167,
title = "Central hypothyroidism",
abstract = "Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary lesions. The diagnosis rests on documentation of clinical and biochemical hypothyroidism with an inappropriately low or nonelevated serum TSH level. Recent studies suggest that the temporal pattern of TSH secretion, as well as TSH structure, is altered in central hypothyroidism, providing a mechanism for the induction of the hypothyroid state in this condition.",
author = "Mary Samuels and Ridgway, {E. C.}",
year = "1992",
language = "English (US)",
volume = "21",
pages = "903--919",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Central hypothyroidism

AU - Samuels, Mary

AU - Ridgway, E. C.

PY - 1992

Y1 - 1992

N2 - Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary lesions. The diagnosis rests on documentation of clinical and biochemical hypothyroidism with an inappropriately low or nonelevated serum TSH level. Recent studies suggest that the temporal pattern of TSH secretion, as well as TSH structure, is altered in central hypothyroidism, providing a mechanism for the induction of the hypothyroid state in this condition.

AB - Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary lesions. The diagnosis rests on documentation of clinical and biochemical hypothyroidism with an inappropriately low or nonelevated serum TSH level. Recent studies suggest that the temporal pattern of TSH secretion, as well as TSH structure, is altered in central hypothyroidism, providing a mechanism for the induction of the hypothyroid state in this condition.

UR - http://www.scopus.com/inward/record.url?scp=0026620738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026620738&partnerID=8YFLogxK

M3 - Article

C2 - 1486881

AN - SCOPUS:0026620738

VL - 21

SP - 903

EP - 919

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 4

ER -