Central distal axonopathy syndromes: Newly recognized models of naturally occurring human degenerative disease

P. K. Thomas, H. H. Schaumburg, Peter Spencer, H. E. Kaeser, C. A. Pallis, F. C. Rose, N. H. Wadia

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A neurotoxic substance may be both an environmental hazard and a useful tool for the neuroscientist. Recent examples include the establishment of the central-peripheral distal axonopathy of human acrylamide intoxication as a model of spinocerebellar degeneration, and the use of selective neuronopathic destruction of the human substantia nigra by methylphenyltetrahydropyridine as a new approach to the study of Parkinson's disease. Careful study of experimental animal models of such toxic conditions can contribute to the elucidation of the pathophysiological and biochemical mechanisms underlying the naturally occurring human conditions.

Original languageEnglish (US)
Pages (from-to)313-315
Number of pages3
JournalAnnals of Neurology
Volume15
Issue number4
StatePublished - 1984
Externally publishedYes

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Spinocerebellar Degenerations
Acrylamide
Poisons
Substantia Nigra
Parkinson Disease
Animal Models

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Thomas, P. K., Schaumburg, H. H., Spencer, P., Kaeser, H. E., Pallis, C. A., Rose, F. C., & Wadia, N. H. (1984). Central distal axonopathy syndromes: Newly recognized models of naturally occurring human degenerative disease. Annals of Neurology, 15(4), 313-315.

Central distal axonopathy syndromes : Newly recognized models of naturally occurring human degenerative disease. / Thomas, P. K.; Schaumburg, H. H.; Spencer, Peter; Kaeser, H. E.; Pallis, C. A.; Rose, F. C.; Wadia, N. H.

In: Annals of Neurology, Vol. 15, No. 4, 1984, p. 313-315.

Research output: Contribution to journalArticle

Thomas, PK, Schaumburg, HH, Spencer, P, Kaeser, HE, Pallis, CA, Rose, FC & Wadia, NH 1984, 'Central distal axonopathy syndromes: Newly recognized models of naturally occurring human degenerative disease', Annals of Neurology, vol. 15, no. 4, pp. 313-315.
Thomas, P. K. ; Schaumburg, H. H. ; Spencer, Peter ; Kaeser, H. E. ; Pallis, C. A. ; Rose, F. C. ; Wadia, N. H. / Central distal axonopathy syndromes : Newly recognized models of naturally occurring human degenerative disease. In: Annals of Neurology. 1984 ; Vol. 15, No. 4. pp. 313-315.
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