Central control of thermogenesis in mammals

Research output: Contribution to journalArticle

280 Citations (Scopus)

Abstract

Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature in mammals and birds during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. The primary sources of neurally regulated metabolic heat production are mitochondrial oxidation in brown adipose tissue, increases in heart rate and shivering in skeletal muscle. Thermogenesis is regulated in each of these tissues by parallel networks in the central nervous system, which respond to feedforward afferent signals from cutaneous and core body thermoreceptors and to feedback signals from brain thermosensitive neurons to activate the appropriate sympathetic and somatic efferents. This review summarizes the research leading to a model of the feedforward reflex pathway through which environmental cold stimulates thermogenesis and discusses the influence on this thermoregulatory network of the pyrogenic mediator, prostaglandin E2, to increase body temperature. The cold thermal afferent circuit from cutaneous thermal receptors ascends via second-order thermosensory neurons in the dorsal horn of the spinal cord to activate neurons in the lateral parabrachial nucleus, which drive GABAergic interneurons in the preoptic area to inhibit warm-sensitive, inhibitory output neurons of the preoptic area. The resulting disinhibition of thermogenesis-promoting neurons in the dorsomedial hypothalamus and possibly of sympathetic and somatic premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, activates excitatory inputs to spinal sympathetic and somatic motor circuits to drive thermogenesis.

Original languageEnglish (US)
Pages (from-to)773-797
Number of pages25
JournalExperimental Physiology
Volume93
Issue number7
DOIs
StatePublished - Jul 2008

Fingerprint

Thermogenesis
Mammals
Neurons
Body Temperature
Preoptic Area
Thermoreceptors
Hot Temperature
Shivering
Posterior Horn Cells
Skin
Brown Adipose Tissue
Interneurons
Dinoprostone
Hypothalamus
Birds
Reflex
Skeletal Muscle
Fever
Central Nervous System
Heart Rate

ASJC Scopus subject areas

  • Physiology

Cite this

Central control of thermogenesis in mammals. / Morrison, Shaun; Nakamura, Kazuhiro; Madden, Christopher (Chris).

In: Experimental Physiology, Vol. 93, No. 7, 07.2008, p. 773-797.

Research output: Contribution to journalArticle

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