Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Virginia L. Brooks; Kyung Woo Cho; Richard L. Malvin; Bennett J. Cohen

doi:10.3181/00379727-165-40950

Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Virginia L. Brooks, Kyung Woo Cho, Richard L. Malvin, Bennett J. Cohen

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	165
Issue number	1
DOIs	https://doi.org/10.3181/00379727-165-40950
State	Published - Oct 1980
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3181/00379727-165-40950

Cite this

@article{a4efe6f466d540a1aef92a513b781f27,

title = "Central and Hormonal Regulation of Renin Release by Baboon Kidneys",

abstract = "Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.",

author = "Brooks, {Virginia L.} and Cho, {Kyung Woo} and Malvin, {Richard L.} and Cohen, {Bennett J.}",

year = "1980",

month = oct,

doi = "10.3181/00379727-165-40950",

language = "English (US)",

volume = "165",

pages = "147--150",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "SAGE Publications Ltd",

number = "1",

}

TY - JOUR

T1 - Central and Hormonal Regulation of Renin Release by Baboon Kidneys

AU - Brooks, Virginia L.

AU - Cho, Kyung Woo

AU - Malvin, Richard L.

AU - Cohen, Bennett J.

PY - 1980/10

Y1 - 1980/10

N2 - Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

AB - Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

UR - http://www.scopus.com/inward/record.url?scp=0019219426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019219426&partnerID=8YFLogxK

U2 - 10.3181/00379727-165-40950

DO - 10.3181/00379727-165-40950

M3 - Article

C2 - 6252557

AN - SCOPUS:0019219426

SN - 0037-9727

VL - 165

SP - 147

EP - 150

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 1

ER -

Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this