Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Virginia L. Brooks, Kyung Woo Cho, Richard L. Malvin, Bennett J. Cohen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume165
Issue number1
DOIs
StatePublished - Oct 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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