Central action of increased osmolality to support blood pressure in deoxycorticosterone acetate-salt rats

Theresa L. O'Donaughy, Qi Yue, Virginia Brooks

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To test the hypothesis that increased osmolality contributes to hypertension in deoxycorticosterone acetate (DOCA)-salt-hypertensive rats by acting in the brain, DOCA-salt and Sham-salt rats were instrumented with bilateral, nonoccluding intracarotid and femoral catheters. Two weeks prior, rats were uninephrectomized and received subcutaneous implants with or without DOCA (65 mg) and began drinking salt water (1% NaCl and 0.2% KCl). DOCA-salt rats (n=28) exhibited elevated blood pressure (159±4 mm Hg; P

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalHypertension
Volume48
Issue number4
DOIs
StatePublished - Oct 2006

Fingerprint

Desoxycorticosterone
Osmolar Concentration
Acetates
Salts
Blood Pressure
Thigh
Drinking Water
Catheters
Hypertension
Brain

Keywords

  • Central nervous system
  • Hypertension, mineralocorticoid
  • Hypertension, sodium-dependent
  • Sodium
  • Sympathetic nervous system
  • Vasopressin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Central action of increased osmolality to support blood pressure in deoxycorticosterone acetate-salt rats. / O'Donaughy, Theresa L.; Yue, Qi; Brooks, Virginia.

In: Hypertension, Vol. 48, No. 4, 10.2006, p. 658-663.

Research output: Contribution to journalArticle

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