Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease

Investigation of a possible mechanism of action

Amala Soumyanath, Yong Ping Zhong, Edward Henson, Teri Wadsworth, James Bishop, Bruce G. Gold, Joseph Quinn

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high -amyloid burden. Orally administered GKW attenuated -amyloid-associated behavioral abnormalities in these mice. In vitro, GKW protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated -amyloid, respectively. GKW prevented intracellular -amyloid aggregate formation in MC65 cells. GKW did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current AD therapies. GKW is rich in phenolic compounds and does not contain asiatic acid, a known CA neuroprotective triterpene. CA thus offers a unique therapeutic mechanism and novel active compounds of potential relevance to the treatment of AD.

Original languageEnglish (US)
Article number381974
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - 2012

Fingerprint

Centella
Alzheimer Disease
Amyloid
Triterpenes
Cholinesterase Inhibitors
Neuroblastoma
Glutamic Acid
Centella asiatica extract
Neurons
Water
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Aging
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease : Investigation of a possible mechanism of action. / Soumyanath, Amala; Zhong, Yong Ping; Henson, Edward; Wadsworth, Teri; Bishop, James; Gold, Bruce G.; Quinn, Joseph.

In: International Journal of Alzheimer's Disease, 2012.

Research output: Contribution to journalArticle

@article{f548a8390cc74abc9dcaf81cb3218307,
title = "Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease: Investigation of a possible mechanism of action",
abstract = "Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high -amyloid burden. Orally administered GKW attenuated -amyloid-associated behavioral abnormalities in these mice. In vitro, GKW protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated -amyloid, respectively. GKW prevented intracellular -amyloid aggregate formation in MC65 cells. GKW did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current AD therapies. GKW is rich in phenolic compounds and does not contain asiatic acid, a known CA neuroprotective triterpene. CA thus offers a unique therapeutic mechanism and novel active compounds of potential relevance to the treatment of AD.",
author = "Amala Soumyanath and Zhong, {Yong Ping} and Edward Henson and Teri Wadsworth and James Bishop and Gold, {Bruce G.} and Joseph Quinn",
year = "2012",
doi = "10.1155/2012/381974",
language = "English (US)",
journal = "International Journal of Alzheimer's Disease",
issn = "2090-8024",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease

T2 - Investigation of a possible mechanism of action

AU - Soumyanath, Amala

AU - Zhong, Yong Ping

AU - Henson, Edward

AU - Wadsworth, Teri

AU - Bishop, James

AU - Gold, Bruce G.

AU - Quinn, Joseph

PY - 2012

Y1 - 2012

N2 - Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high -amyloid burden. Orally administered GKW attenuated -amyloid-associated behavioral abnormalities in these mice. In vitro, GKW protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated -amyloid, respectively. GKW prevented intracellular -amyloid aggregate formation in MC65 cells. GKW did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current AD therapies. GKW is rich in phenolic compounds and does not contain asiatic acid, a known CA neuroprotective triterpene. CA thus offers a unique therapeutic mechanism and novel active compounds of potential relevance to the treatment of AD.

AB - Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high -amyloid burden. Orally administered GKW attenuated -amyloid-associated behavioral abnormalities in these mice. In vitro, GKW protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated -amyloid, respectively. GKW prevented intracellular -amyloid aggregate formation in MC65 cells. GKW did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current AD therapies. GKW is rich in phenolic compounds and does not contain asiatic acid, a known CA neuroprotective triterpene. CA thus offers a unique therapeutic mechanism and novel active compounds of potential relevance to the treatment of AD.

UR - http://www.scopus.com/inward/record.url?scp=84858240537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858240537&partnerID=8YFLogxK

U2 - 10.1155/2012/381974

DO - 10.1155/2012/381974

M3 - Article

JO - International Journal of Alzheimer's Disease

JF - International Journal of Alzheimer's Disease

SN - 2090-8024

M1 - 381974

ER -