Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions

Andreas Füssl, Andreas Schleifenbaum, Mareike Göritz, Andrew Riddell, Carsten Schultz, Roland Krämer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.

Original languageEnglish (US)
Pages (from-to)5986-5987
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number18
DOIs
StatePublished - May 10 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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