Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions

Andreas Füssl, Andreas Schleifenbaum, Mareike Göritz, Andrew Riddell, Carsten Schultz, Roland Krämer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.

Original languageEnglish (US)
Pages (from-to)5986-5987
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number18
DOIs
StatePublished - May 10 2006
Externally publishedYes

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Peptide Nucleic Acids
Chelating Agents
HeLa Cells
Cultured Cells
Ions

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions. / Füssl, Andreas; Schleifenbaum, Andreas; Göritz, Mareike; Riddell, Andrew; Schultz, Carsten; Krämer, Roland.

In: Journal of the American Chemical Society, Vol. 128, No. 18, 10.05.2006, p. 5986-5987.

Research output: Contribution to journalArticle

Füssl, A, Schleifenbaum, A, Göritz, M, Riddell, A, Schultz, C & Krämer, R 2006, 'Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions', Journal of the American Chemical Society, vol. 128, no. 18, pp. 5986-5987. https://doi.org/10.1021/ja0571139
Füssl, Andreas ; Schleifenbaum, Andreas ; Göritz, Mareike ; Riddell, Andrew ; Schultz, Carsten ; Krämer, Roland. / Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 18. pp. 5986-5987.
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