Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation

Nathan Selden, Daniel J. Guillaume, Robert D. Steiner, Stephen L. Huhn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

Original languageEnglish (US)
Article numberE22
JournalNeurosurgical Focus
Volume24
Issue number3-4
DOIs
StatePublished - Mar 2008

Fingerprint

Neurodegenerative Diseases
Clinical Trials
Neural Stem Cells
Central Nervous System Diseases
Cell- and Tissue-Based Therapy
Ethics
Patient Selection
Transplantation
Therapeutics
In Vitro Techniques

Keywords

  • Cell replacements therapy
  • Cell transplantation
  • Central nervous system clinical trial
  • Neural stem cell
  • Neurodegenerative diease
  • Restorative neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Cellular therapy for childhood neurodegenerative disease. Part II : Clinical trial design and implementation. / Selden, Nathan; Guillaume, Daniel J.; Steiner, Robert D.; Huhn, Stephen L.

In: Neurosurgical Focus, Vol. 24, No. 3-4, E22, 03.2008.

Research output: Contribution to journalArticle

Selden, Nathan ; Guillaume, Daniel J. ; Steiner, Robert D. ; Huhn, Stephen L. / Cellular therapy for childhood neurodegenerative disease. Part II : Clinical trial design and implementation. In: Neurosurgical Focus. 2008 ; Vol. 24, No. 3-4.
@article{d28392b4a84148b5a4d85f641c86d3f4,
title = "Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation",
abstract = "Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.",
keywords = "Cell replacements therapy, Cell transplantation, Central nervous system clinical trial, Neural stem cell, Neurodegenerative diease, Restorative neurosurgery",
author = "Nathan Selden and Guillaume, {Daniel J.} and Steiner, {Robert D.} and Huhn, {Stephen L.}",
year = "2008",
month = "3",
doi = "10.3171/FOC/2008/24/3-4/E21",
language = "English (US)",
volume = "24",
journal = "Neurosurgical Focus",
issn = "1092-0684",
publisher = "American Association of Neurological Surgeons",
number = "3-4",

}

TY - JOUR

T1 - Cellular therapy for childhood neurodegenerative disease. Part II

T2 - Clinical trial design and implementation

AU - Selden, Nathan

AU - Guillaume, Daniel J.

AU - Steiner, Robert D.

AU - Huhn, Stephen L.

PY - 2008/3

Y1 - 2008/3

N2 - Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

AB - Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

KW - Cell replacements therapy

KW - Cell transplantation

KW - Central nervous system clinical trial

KW - Neural stem cell

KW - Neurodegenerative diease

KW - Restorative neurosurgery

UR - http://www.scopus.com/inward/record.url?scp=42149084678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42149084678&partnerID=8YFLogxK

U2 - 10.3171/FOC/2008/24/3-4/E21

DO - 10.3171/FOC/2008/24/3-4/E21

M3 - Article

C2 - 18341400

AN - SCOPUS:42149084678

VL - 24

JO - Neurosurgical Focus

JF - Neurosurgical Focus

SN - 1092-0684

IS - 3-4

M1 - E22

ER -