Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation

Nathan R. Selden; Daniel J. Guillaume; Robert D. Steiner; Stephen L. Huhn

doi:10.3171/FOC/2008/24/3-4/E21

Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation

Nathan R. Selden, Daniel J. Guillaume, Robert D. Steiner, Stephen L. Huhn

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

Original language	English (US)
Article number	E22
Journal	Neurosurgical focus
Volume	24
Issue number	3-4
DOIs	https://doi.org/10.3171/FOC/2008/24/3-4/E21
State	Published - Mar 2008

Keywords

Cell replacements therapy
Cell transplantation
Central nervous system clinical trial
Neural stem cell
Neurodegenerative diease
Restorative neurosurgery

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.3171/FOC/2008/24/3-4/E21

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title = "Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation",

abstract = "Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.",

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AU - Huhn, Stephen L.

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N2 - Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

AB - Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

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KW - Cell transplantation

KW - Central nervous system clinical trial

KW - Neural stem cell

KW - Neurodegenerative diease

KW - Restorative neurosurgery

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Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation

Abstract

Keywords

ASJC Scopus subject areas

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